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Effect of statins on clinical and molecular responses to intramuscular interferon beta-1a.

Author: AppachiS, CalabresiP A, ConfavreuxC, GalettaS L, HydeR, LublinF D, MaurerS L, PaceA, PanzaraM, RadueE-W, RaniM R S, RansohoffR M, RudickR A, ShrockJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Statin therapy did not appear to affect the clinical effects of interferon beta-1a in patients with relapsing-remitting multiple sclerosis or the primary molecular response to interferon beta treatment.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Findings from a small clinical study suggested that statins may counteract the therapeutic effects of interferon beta (IFNbeta) in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: We conducted a post hoc analysis of data from the Safety and Efficacy of Natalizumab i...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837592/

データ提供：米国国立医学図書館（NLM）

Investigating the Interaction of Statins and Interferon Beta

This research explores the potential interactions between statins, commonly used to lower cholesterol, and interferon beta (IFNbeta), a medication used to treat multiple sclerosis (MS). Imagine a desert traveler seeking a cure for a debilitating illness, while also needing to manage their overall health. This study examines the interplay between two vital medications, ensuring their safe and effective use for patients with MS.

Statins and Interferon Beta: A Complex Relationship

The study provides reassuring findings regarding the compatibility of statins and IFNbeta in patients with relapsing-remitting MS. Researchers found no significant differences in clinical or MRI outcomes between patients taking statins and those not taking statins. These findings suggest that statins do not interfere with the therapeutic effects of IFNbeta.

Ensuring Safe and Effective MS Treatment

While the study demonstrates the safety of statins alongside IFNbeta, it highlights the importance of monitoring patients for potential side effects, such as fatigue, muscle aches, and increased hepatic transaminases. It underscores the need for a holistic approach to MS management, considering the individual needs of each patient and ensuring their overall well-being.

Dr.Camel's Conclusion

Navigating the desert of MS requires a multifaceted approach, often involving a combination of medications. This study reassures us of the compatibility of statins and IFNbeta, providing valuable insights for safe and effective treatment. It reminds us that each patient's journey is unique and requires personalized care to ensure optimal outcomes.

Date :
  1. Date Completed 2009-08-03
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19506220

DOI: Digital Object Identifier

PMC2837592

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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