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Management of sorafenib, sunitinib, and temsirolimus toxicity in metastatic renal cell carcinoma.

Author: AlaskerAhmed, GuevremontCatherine, KarakiewiczPierre I

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Sorafenib, sunitinib, and temsirolimus are tyrosine kinase inhibitors (TKIs) commonly used in cancer treatment. Common side effects of sorafenib include lymphopenia, hypophosphatemia, elevated lipase, hand-foot syndrome, and mucositis/stomatitis. Sunitinib may cause elevated lipase, neutropenia, lymphopenia, hypertension, and fatigue/asthenia. Common side effects of temsirolimus are anemia, hyperglycemia, fatigue/asthenia, dyspnea, and hypophosphatemia.
Paper Details　
Original Abstract of the Article :
PURPOSE OF REVIEW: To review the common and serious toxicities associated with the use of tyrosine kinase inhibitors such as sorafenib and sunitinib and mTOR inhibitor temsirolimus, and to outline the most recent toxicity management guidelines. RECENT FINDINGS: Common grade 3 or 4 side effects with...See full text at original site
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引用元：
https://doi.org/10.1097/SPC.0b013e32832e4681

データ提供：米国国立医学図書館（NLM）

Navigating the Side Effects of Targeted Therapies in Renal Cancer

The journey to treat metastatic renal cell carcinoma (mRCC) can be challenging, with targeted therapies like sorafenib, sunitinib, and temsirolimus playing a vital role. However, these medications can sometimes cause side effects, making the treatment landscape a bit like a desert with hidden dangers. This review focuses on understanding and managing these side effects, offering guidance for clinicians and patients. It highlights common grade 3 or 4 side effects associated with these therapies, including lymphopenia, hypophosphatemia, elevated lipase, hand-foot syndrome, and mucositis/stomatitis.

Managing Side Effects: A Balance of Benefits and Risks

The review emphasizes the importance of balancing the benefits of targeted therapies with the potential for adverse events. It provides practical strategies for managing these side effects, such as preventive and therapeutic measures, which aim to minimize the impact on patients' lives while maximizing the effectiveness of treatment.

Understanding the Terrain of Side Effects: A Guide for Patients and Clinicians

This review serves as a valuable guide for both patients and clinicians navigating the terrain of targeted therapies for mRCC. It provides a comprehensive overview of common side effects, highlighting the importance of early identification and management. Armed with this knowledge, patients and clinicians can work together to achieve the best possible treatment outcomes while minimizing the impact of side effects.

Dr. Camel's Conclusion

Like a desert traveler equipped with a map and compass, understanding the potential side effects of targeted therapies for metastatic renal cell carcinoma is crucial for navigating this challenging treatment journey. This review provides valuable insights into managing these side effects, empowering both patients and clinicians to make informed decisions and optimize treatment outcomes.

Date :
  1. Date Completed 2009-12-02
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

19528803

DOI: Digital Object Identifier

10.1097/SPC.0b013e32832e4681

Related Literature

Article Analysis
・Side Effects of temsirolimus
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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