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[Establishment of pharmacological evaluation system for non-nucleoside reverse-transcriptase inhibitors resistant HIV-1].

Author: CaoYing-li, ChenHong, GuoYing, LiShao-xiong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study established a series of cell-based models that can be used to evaluate the efficacy of non-nucleoside reverse-transcriptase inhibitors (NNRTIs) against HIV-1 strains resistant to commonly used NNRTIs. The models are safe to use in a BSL-2 laboratory and can be used for screening new NNRTIs.
Paper Details　
Original Abstract of the Article :
Consistent non-nucleoside reverse-transcriptase inhibitors (NNRTIs) resistant HIV-1 strains occurred due to the clinical use for more than ten years of efavirenz (EFV), nevirapine (NVP), and delavirdine (DLV). In this study, we established nine cell-based pharmacological models according to most NNR...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/19545051

データ提供：米国国立医学図書館（NLM）

NNRTIs Resistant HIV-1: A Shifting Sands of Resistance

The desert of HIV research is a constant battleground, with the virus constantly evolving and developing resistance to medications. This study focuses on the development of non-nucleoside reverse-transcriptase inhibitors (NNRTIs) resistant HIV-1 strains. Researchers have established nine cell-based pharmacological models to assess the effectiveness of NNRTIs against these resistant strains, providing valuable tools for developing new therapies.

NNRTIs Resistant HIV-1: A New Oasis of Research

This study describes the establishment of nine cell-based pharmacological models for evaluating the activity of NNRTIs against NNRTIs-resistant HIV-1 strains. These models are designed to mimic the resistance patterns observed in clinical settings, offering a valuable tool for developing and testing new NNRTIs. The researchers successfully introduced specific mutations into the HIV-1 genome to create resistant strains and demonstrated their resistance to EFV and NVP, while remaining susceptible to nucleoside reverse-transcriptase inhibitors (AZT and d4T).

NNRTIs Resistant HIV-1: A New Path to Treatment

This research provides a critical step forward in the fight against HIV. By developing these cell-based models, researchers can more effectively assess the efficacy of new NNRTIs against resistant HIV strains. This research is essential for developing new therapies that can effectively combat the ever-evolving challenge of HIV resistance.

Dr.Camel's Conclusion

This study highlights the importance of ongoing research into HIV resistance mechanisms and the development of new therapies that can overcome these challenges. The development of these cell-based models provides a valuable tool for assessing the effectiveness of NNRTIs against resistant HIV strains. It's a reminder that the desert of HIV research is a constant battleground, requiring continuous innovation and effort to find new oases of hope for patients.

Date :
  1. Date Completed 2010-04-05
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

19545051

DOI: Digital Object Identifier

19545051

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Languages

Chinese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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