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Efficacy of clonidine, guanfacine and methadone in the rapid detoxification of heroin addicts: a controlled clinical trial.

Author: CamíJ, MataR, PeriJ M, PortaM, SanL

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Methadone was more effective than clonidine and guanfacine in rapid detoxification of heroin inpatients, with fewer withdrawal symptoms.
Paper Details　
Original Abstract of the Article :
The efficacy of clonidine, methadone, and guanfacine in rapid detoxification of heroin inpatients was assessed in a randomized controlled clinical trial. Signs and symptoms of abstinence and of side effects were analysed in 90 heroin addicts successfully completing a 12-day inpatient trial. All pati...See full text at original site
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引用元：
https://doi.org/10.1111/j.1360-0443.1990.tb00634.x

データ提供：米国国立医学図書館（NLM）

Rapid Detoxification of Heroin: A Comparison of Medications

Addiction is a complex and challenging condition, like a desert that can easily trap those who wander within its boundaries. This study examines three medications – clonidine, guanfacine, and methadone – used in rapid detoxification of heroin addiction. The researchers, armed with their scientific expertise, conducted a randomized controlled trial involving 90 heroin addicts who were successfully detoxified over a 12-day inpatient program.

Methadone: A Superior Choice

The study found that all three medications were effective in controlling heroin withdrawal symptoms. However, methadone was found to be superior to clonidine and guanfacine in suppressing withdrawal symptoms. Methadone was particularly effective in reducing withdrawal symptoms during the early stages of detoxification, while clonidine and guanfacine were slightly more effective at the end of the program. The study also noted that the incidence of side effects was related to the dose administered.

Navigating the Desert of Addiction

This study highlights the importance of finding the right treatment approach for individuals struggling with addiction. It shows that different medications can have varying levels of effectiveness and side effects. For those struggling with heroin addiction, this study suggests that methadone may be a more effective option for rapid detoxification, offering a better chance of successfully navigating the challenging path to recovery.

Dr.Camel's Conclusion

This research is like a beacon of hope in the vast desert of addiction. The study provides valuable insights into the effectiveness of different medications used in rapid detoxification of heroin. Methadone emerges as a potentially superior option, offering a better chance of successfully navigating the challenging path to recovery. However, it’s important to remember that each individual’s journey is unique and the best treatment plan is the one that is personalized to their specific needs.
Date :
  1. Date Completed 1990-04-20
  2. Date Revised 2019-09-18
Further Info :

Pubmed ID

1968773

DOI: Digital Object Identifier

10.1111/j.1360-0443.1990.tb00634.x

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・Side Effects of guanfacine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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