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Effect of fibrates on lipid profiles and cardiovascular outcomes: a systematic review.

Author: AbourbihSamuel, EisenbergMark J, FilionKristian B, GenestJacques, JosephLawrence, PiloteLouise, PoirierPaul, RinfretStephane, SchiffrinErnesto L

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Fibrates were associated with greater reductions in total cholesterol and triglycerides and a greater increase in high-density lipoprotein compared with placebo. Fibrates were more efficacious than placebo at preventing nonfatal myocardial infarction.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Fibrates might represent a viable treatment option for patients who do not meet their target low-density lipoprotein levels on statins or who are resistant or intolerant to statins. New data from fibrate trials can be synthesized with the existing literature to better estimate their effec...See full text at original site
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引用元：
https://doi.org/10.1016/j.amjmed.2009.03.030

データ提供：米国国立医学図書館（NLM）

Fibrates: A Potential Solution for Lipid Management

This research delves into the realm of lipid management, an area as complex and challenging as navigating a shifting sand dune. The authors conducted a systematic review to assess the effectiveness of fibrates, a class of medications used to lower cholesterol and triglycerides, in improving lipid profiles and reducing cardiovascular risks. They meticulously analyzed the available evidence, seeking to clarify the role of fibrates in cardiovascular health.

Fibrates: A Promising Tool for Cardiovascular Health

This study, like a well-defined path through a desert, reveals that fibrates can be a valuable tool for managing lipid levels and reducing the risk of cardiovascular events. The authors found that fibrates were associated with significant reductions in total cholesterol and triglycerides, while increasing high-density lipoprotein levels. Their analysis also showed that fibrates reduced the incidence of nonfatal myocardial infarction, highlighting their potential benefits for cardiovascular health.

Fibrates: A Potential Solution for Challenging Lipid Profiles

This research, like a refreshing oasis in the desert, offers hope for individuals struggling with challenging lipid profiles. The authors' findings suggest that fibrates can be a valuable treatment option for those who do not respond adequately to statins or who experience statin intolerance. This study provides valuable insights into the role of fibrates in cardiovascular health, underscoring their potential to improve lipid profiles and reduce the risk of heart disease.

Dr.Camel's Conclusion

This review, like a compass guiding a traveler through the desert, sheds light on the potential benefits of fibrates for managing lipid levels and reducing cardiovascular risks. The authors' findings suggest that fibrates can be a valuable addition to the arsenal of therapies available for addressing cardiovascular health concerns. This research is a reminder that ongoing research and careful consideration of treatment options are essential for optimizing patient care and improving cardiovascular outcomes.

Date :
  1. Date Completed 2009-10-15
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

19698935

DOI: Digital Object Identifier

10.1016/j.amjmed.2009.03.030

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・Effective treatment of statins
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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