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Statins and fibrate target ClC-1 - from side effects to CLC pharmacology.

Author: ZdebikAnselm A

CommentA short article/note that provides an opinion/perspective/interpretation on a published paper/topic.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study found that two statins and fenofibrate, often used in combination, decrease function of the chloride channel member 1 of the mammalian CLC protein family of chloride channels and transporters in skeletal muscle by three distinct mechanisms.
Paper Details　
Original Abstract of the Article :
Lipid-lowering drugs have been associated with severe adverse effects on skeletal muscle, including rhabdomyolysis. More common symptoms include cramps and myalgia. In this issue of the BJP, Pierno et al. find that two statins and fenofibrate, often used in combination, decrease function of the chlo...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697727/

データ提供：米国国立医学図書館（NLM）

Unveiling the Hidden Side Effects of Lipid-Lowering Drugs

Lipid-lowering drugs, often prescribed to manage cholesterol levels, have been linked to muscle-related side effects, including rhabdomyolysis. This study examines the impact of statins and fibrates on a specific chloride channel, CLC-1, found in skeletal muscle, shedding light on the mechanisms behind these side effects.

Unmasking the Mechanisms of Muscle Side Effects

The study reveals that statins and fibrates can decrease the function of CLC-1, a crucial chloride channel involved in muscle function. This finding provides valuable insight into the mechanisms underlying the muscle-related side effects of these drugs. Further research into CLC protein pharmacology could lead to a better understanding and management of these side effects.

Understanding the Potential Risks

The study emphasizes the importance of understanding the potential risks associated with lipid-lowering drugs. It’s crucial to discuss any muscle-related symptoms with your healthcare provider, especially if you’re taking these medications. Just as a desert traveler must be aware of the dangers of dehydration, it’s vital to be mindful of potential side effects and discuss them with your healthcare provider.

Dr. Camel's Conclusion

This research is like a desert oasis revealing a hidden spring of knowledge about the effects of lipid-lowering drugs. The study’s findings provide valuable insights into the potential mechanisms behind muscle-related side effects, reminding us that even seemingly benign medications can have unexpected consequences. It’s crucial to approach medical treatments with caution, always seeking guidance from a trusted healthcare professional.

Date :
  1. Date Completed 2010-01-05
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19751314

DOI: Digital Object Identifier

PMC2697727

Related Literature

Article Analysis
・Side Effects of fenofibrate
SNS
PICO Info
in preparation
Languages

English

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