Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation.

Author: BellPatrick M, DuffyNicola A, FlattPeter R, GreenBrian D, LindsayJohn R, McKillopAine M, O'HarteFinbarr P M, PattersonS

Paper Details 
Original Abstract of the Article :
Nateglinide restores early-phase insulin secretion to feeding and reduces postprandial hyperglycaemia in type 2 diabetes. This study evaluated the effects of nateglinide on dipeptidyl peptidase-IV (DPP-IV) activity and glucose-dependent insulinotropic polypeptide (GIP) degradation. Research design a...See full text at original site
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引用元:
https://doi.org/10.1530/EJE-09-0547

データ提供:米国国立医学図書館(NLM)

Nateglinide: A Desert Oasis for Type 2 Diabetes?

This study explores the effects of nateglinide, a medication used to treat type 2 diabetes, on insulin secretion and glucose regulation. The researchers investigated the effects of nateglinide on dipeptidyl peptidase-IV (DPP-IV) activity and glucose-dependent insulinotropic polypeptide (GIP) degradation, a complex interplay akin to the delicate balance of an ecosystem in the desert.

Restoring balance: Nateglinide and insulin secretion

The study found that nateglinide, like a refreshing oasis in the desert, can restore early-phase insulin secretion in response to feeding and reduce postprandial hyperglycemia in type 2 diabetes. This suggests that nateglinide can help improve glucose control by enhancing the body's natural ability to regulate blood sugar. The researchers also found that nateglinide doesn't seem to have a significant impact on DPP-IV activity or GIP degradation, suggesting a targeted effect on insulin secretion.

A new perspective: Type 2 diabetes management

This research offers a promising perspective on the management of type 2 diabetes. The study's findings suggest that nateglinide can be a valuable tool for enhancing insulin secretion and improving glucose control in individuals with type 2 diabetes. This could lead to better management of the disease and potentially improve long-term health outcomes.

Dr.Camel's Conclusion

This study explores the intricate mechanisms behind nateglinide's effects on insulin secretion and glucose regulation. Like a camel navigating a desert, the body must carefully regulate its glucose levels for optimal health. This research offers a promising avenue for improving the management of type 2 diabetes by targeting specific pathways that influence insulin secretion. It's a testament to the power of scientific research in uncovering new strategies for tackling this challenging condition.

Date :
  1. Date Completed 2009-12-11
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

19755410

DOI: Digital Object Identifier

10.1530/EJE-09-0547

Related Literature

SNS
PICO Info
in preparation
Languages

English

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