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The effects of particle properties on nanoparticle drug retention and release in dynamic minoxidil foams.

Author: BrownMarc B, JonesStuart A, ZhaoYanjun

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lipid and polymeric nanoparticles can be formulated as aqueous suspensions or dynamic hydrofluoroalkane foams to deliver minoxidil to the skin. Drug release and permeation are influenced by nanoparticle properties.
Paper Details　
Original Abstract of the Article :
Nanocarriers may act as useful tools to deliver therapeutic agents to the skin. However, balancing the drug-particle interactions; to ensure adequate drug loading, with the drug-vehicle interactions; to allow efficient drug release, presents a significant challenge using traditional semi-solid vehic...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijpharm.2009.09.029

データ提供：米国国立医学図書館（NLM）

Nanoparticle Drug Delivery for Minoxidil: Navigating the Desert of Topical Delivery

The [desert of topical drug delivery] is a challenging landscape, where [achieving effective and controlled drug release] can be elusive. This study explores [the use of nanocarriers to deliver minoxidil to the skin], investigating the [influence of particle properties on drug retention and release] within [dynamic foams]. The authors employ [a combination of nanoparticle formulation and dynamic foam technology] to [optimize minoxidil delivery], seeking to [maximize efficacy and minimize side effects].

The Shifting Sands of Drug Release

The research reveals that [particle properties significantly influence drug release] from [topical formulations]. The authors highlight [the importance of balancing drug-particle and drug-vehicle interactions] to [ensure effective drug loading and controlled release].

Navigating the Desert of Topical Delivery

This study provides valuable insights into [the optimization of nanoparticle drug delivery systems] for [topical applications]. The authors' findings encourage [further exploration of the interplay between particle properties and foam formulations] to [develop more effective and efficient drug delivery systems].

Dr.Camel's Conclusion

This research takes us on a journey through the [desert of topical drug delivery], illuminating the complexities of [nanoparticle-based formulations] in [foams]. The authors' findings provide valuable insights into [the potential for optimizing drug release] and [improving the efficacy of topical therapies].

Date :
  1. Date Completed 2010-07-29
  2. Date Revised 2022-03-09
Further Info :

Pubmed ID

19772905

DOI: Digital Object Identifier

10.1016/j.ijpharm.2009.09.029

Related Literature

Article Analysis
・Effects of minoxidil
SNS
PICO Info
in preparation
Languages

English

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