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A multi-center, open label, crossover designed prospective study evaluating the effects of lipid lowering treatment on steroid synthesis in patients with Type 2 diabetes (MODEST Study).

Author: AltuntasY, ArincH, BolayirliM, CelebiH, DiricanA, KanatM, KaragozY, OguzA, SahinS, SerinE, TunckaleA, YildizO

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Eighty milligrams of atorvastatin decreased all adrenal and gonadal steroids, whereas 10 mg of ezetimibe combined with 10 mg of atorvastatin had at least no impact on cortisol levels.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: It has been suggested that lipid-lowering treatment with the use of statins adversely affects the steroid hormones. However, the safety of lipid lowering treatment targeting very low levels of LDL with respect to the steroid hormones has not been established. RESEARCH DESIGN AND METHODS:...See full text at original site
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引用元：
https://doi.org/10.1007/BF03345757

データ提供：米国国立医学図書館（NLM）

Lipid-Lowering Treatment: A Desert Oasis of Balancing Act

This research explores the complex relationship between [lipid-lowering treatment], specifically using [statins and ezetimibe], and the production of [steroid hormones]. Imagine [lipid-lowering treatment] as a desert oasis, offering potential benefits for cardiovascular health, but potentially impacting other aspects of the body's delicate balance. The authors investigated the effects of [statins and ezetimibe] on the levels of different steroid hormones, aiming to understand the potential impact of these medications on endocrine function.

Lipid-Lowering Treatment: A Desert Oasis of Balance

This study demonstrates that [statins and ezetimibe] can impact the production of [steroid hormones], potentially affecting the balance of hormones in the body. The authors highlight the importance of monitoring [steroid hormone] levels in patients receiving [lipid-lowering treatment] and adjusting treatment strategies accordingly to minimize potential side effects. The study emphasizes the need for a comprehensive approach to managing cardiovascular health, considering the potential impact of medications on overall well-being.

Navigating Lipid-Lowering Treatment: A Desert Oasis of Knowledge

This research underscores the importance of understanding the potential impact of medications on the body's delicate balance, particularly when it comes to [lipid-lowering treatment]. The study highlights the need for careful monitoring of [steroid hormone] levels and emphasizes the importance of individualized treatment plans to optimize patient outcomes and minimize potential side effects. Remember, a healthy body is a balanced body, and it's crucial to work with your doctor to ensure that medications are used appropriately and effectively.

Dr. Camel's Conclusion

This research is like a camel caravan navigating the desert of [lipid-lowering treatment], reminding us to be aware of the potential impact of medications on the body's delicate balance. It highlights the importance of monitoring [steroid hormone] levels and adjusting treatment strategies accordingly to minimize potential side effects. Remember, a healthy body is like a well-maintained oasis, ensuring that all systems function optimally and that we can thrive in the desert of life's challenges.
Date :
  1. Date Completed 2010-03-02
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19783896

DOI: Digital Object Identifier

10.1007/BF03345757

Related Literature

Article Analysis
・Effective treatment of statins
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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