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Misoprostol to prevent and treat postpartum haemorrhage: a systematic review and meta-analysis of maternal deaths and dose-related effects.

Author: FerreiraSandra, GülmezogluA Metin, HofmeyrG Justus, LinderVerena, NovikovaNatalia, PiaggioGilda

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Misoprostol at a dose of 400 microg was found to be safer than > 600 microg and just as effective in preventing blood loss and pyrexia.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To review maternal deaths and the dose-related effects of misoprostol on blood loss and pyrexia in randomized trials of misoprostol use for the prevention or treatment of postpartum haemorrhage. METHODS: We searched the Cochrane Controlled Trials Register and Pubmed, without language res...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739911/

データ提供：米国国立医学図書館（NLM）

Misoprostol: A Valuable Tool for Managing Postpartum Hemorrhage

Postpartum hemorrhage is a serious and potentially life-threatening complication that can occur after childbirth. This research delves into the use of misoprostol, a medication that helps prevent and treat postpartum hemorrhage. The authors conducted a systematic review and meta-analysis of randomized trials, examining the effectiveness and safety of misoprostol in various doses. They provide valuable insights into the benefits and risks of using misoprostol, emphasizing the need for careful dose selection to optimize outcomes.

Navigating the Desert of Postpartum Hemorrhage: A Guide to Misoprostol Dosing

This research provides valuable guidance on the use of misoprostol for preventing and treating postpartum hemorrhage. The authors' meta-analysis highlights the importance of dose selection, emphasizing the potential risks associated with higher doses. The study underscores the need for careful clinical judgment and monitoring when using misoprostol to ensure optimal outcomes.

Protecting Mothers and Infants: A Crucial Role for Misoprostol

Postpartum hemorrhage is a dangerous desert, and misoprostol is a valuable tool for navigating this challenging terrain. This research provides critical insights into the effective and safe use of misoprostol, helping to protect mothers and their newborn infants from the risks of this life-threatening condition.

Dr.Camel's Conclusion

This research underscores the importance of careful dose selection when using misoprostol for postpartum hemorrhage. The authors emphasize the potential risks associated with higher doses, highlighting the need for vigilant monitoring and responsible clinical judgment to ensure safe and effective treatments.

Date :
  1. Date Completed 2009-12-31
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19784446

DOI: Digital Object Identifier

PMC2739911

Related Literature

Article Analysis
・Effects of misoprostol・Effects of mitapivat
SNS
PICO Info
in preparation
Languages

English

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