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Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.

Author: MartínezMiguel Angel, MatamorosTania, Menéndez-AriasLuis, NevotMaría

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Val(75) mutations in HIV-1 reverse transcriptase affect drug resistance patterns. V75I antagonizes thymidine analogue resistance mutations, increasing susceptibility to AZT and d4T.
Paper Details　
Original Abstract of the Article :
Val(75) of HIV-1 reverse transcriptase (RT) plays a role in positioning the template nucleotide +1 during the formation of the ternary complex. Mutations, such as V75M and V75A, emerge in patients infected with HIV-1 group M subtype B and group O variants, after failing treatment with stavudine (d4T...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781696/

データ提供：米国国立医学図書館（NLM）

HIV-1 Reverse Transcriptase: A Complex Landscape of Resistance

This research delves into the complex world of HIV-1 reverse transcriptase (RT), an enzyme crucial for the replication of the HIV virus. The study focuses on the impact of specific mutations in RT, particularly V75I, on the efficacy of thymidine analogue drugs used in HIV treatment. The research sheds light on the intricate interplay between mutations, drug resistance, and the effectiveness of antiviral therapies. This study is like navigating a labyrinthine desert landscape, where each mutation represents a hidden passageway affecting the virus's ability to evade treatment.

Navigating the Shifting Sands of HIV Resistance

The study unveils the intricate interplay between mutations, drug resistance, and the effectiveness of antiviral therapies. The findings highlight the importance of understanding the evolving landscape of HIV-1 RT, enabling the development of more effective and targeted treatments.

Staying Ahead of the Curve in HIV Treatment

This research emphasizes the importance of ongoing monitoring and adaptation of HIV treatment strategies to combat emerging resistance. Just as the desert landscape shifts with time, HIV strains evolve and adapt, demanding continued vigilance and innovation in treatment approaches.

Dr.Camel's Conclusion

This research delves deep into the intricate world of HIV-1 RT, highlighting the challenges of treating a constantly evolving virus. Like a desert traveler navigating shifting dunes, researchers must stay one step ahead of the virus to develop effective therapies.

Date :
  1. Date Completed 2009-12-14
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19801659

DOI: Digital Object Identifier

PMC2781696

Related Literature

Article Analysis
・Effects of stavudine
SNS
PICO Info
in preparation
Languages

English

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