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Meta-analysis of sulfasalazine in ankylosing spondylitis.

Author: AtraE, FerrazM B, GoldsmithC H, TugwellP

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This meta-analysis of five studies assessed the effectiveness of sulfasalazine for treating ankylosing spondylitis (AS). Sulfasalazine showed a significant improvement in several symptoms compared to placebo, including morning stiffness, pain, and general well-being. While side effects were more common with sulfasalazine, these were mostly mild. The study concludes that sulfasalazine is a safe and effective short-term treatment option for AS.
Paper Details　
Original Abstract of the Article :
At present there is no widely accepted therapy for ankylosing spondylitis (AS), a progressive debilitating disease. The effectiveness of sulfasalazine in AS still lacks strong evidence, as well, the magnitude of its benefit is unknown. A meta-analysis was carried out to assess the effectiveness of s...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1980310

データ提供：米国国立医学図書館（NLM）

Meta-Analysis of Sulfasalazine in Ankylosing Spondylitis

This research delves into the world of rheumatology, focusing on the effectiveness of sulfasalazine in treating ankylosing spondylitis (AS), a chronic inflammatory disease affecting the spine. The study, conducted as a meta-analysis, combined data from five randomized controlled trials (RCTs) comparing sulfasalazine to placebo. Their findings indicate that sulfasalazine demonstrates short-term efficacy in reducing symptoms of AS, including morning stiffness, pain, and inflammation. While the study suggests a positive impact, it emphasizes the need for further research to determine the long-term effectiveness and potential for long-term adverse effects.

Sulfasalazine: A Potential Treatment for Ankylosing Spondylitis

This meta-analysis provides evidence for the short-term efficacy of sulfasalazine in treating ankylosing spondylitis. The significant reductions in AS symptoms observed in the sulfasalazine group suggest that this medication could offer relief for patients. However, further research is needed to assess its long-term effectiveness and potential for adverse effects.

Navigating the Challenges of Ankylosing Spondylitis: A Journey of Hope and Research

Ankylosing spondylitis is a chronic condition that can significantly impact quality of life. This meta-analysis offers hope by highlighting the potential benefits of sulfasalazine. Remember, dear readers, ongoing research and a collaborative approach are essential for developing effective treatments for chronic conditions.

Dr. Camel's Conclusion

Just as a camel journeys through the desert, seeking respite from the harsh conditions, those with ankylosing spondylitis search for relief from their symptoms. This meta-analysis provides encouraging evidence for the short-term effectiveness of sulfasalazine. Always remember, dear readers, research and innovation are essential for finding new solutions to manage chronic conditions.

Date :
  1. Date Completed 1991-02-27
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

1980310

DOI: Digital Object Identifier

1980310

SNS
PICO Info
in preparation
Languages

English

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