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The antiarrhythmic effects of ranolazine.

Author: FosterNathan J, HainesDavid E

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Ranolazine is a drug that is approved for the treatment of angina. It is being investigated as a potential antiarrhythmic drug because it can modify ionic currents in cardiac cells, which are responsible for generating action potentials. Unlike other antiarrhythmic drugs, ranolazine is well tolerated and has few side effects.
Paper Details　
Original Abstract of the Article :
The genesis of cardiac arrhythmia can be grouped into 3 common mechanisms: abnormal automaticity, triggered activity, and re-entry. Alteration of automaticity, triggered activity, conduction, and/or refractoriness of myocardial tissue by drugs will perturb and often prevent the occurrence of arrhyth...See full text at original site
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引用元：
https://doi.org/10.3909/ricm10S10006

データ提供：米国国立医学図書館（NLM）

The Antiarrhythmic Effects of Ranolazine

This study explores the [antiarrhythmic potential of ranolazine], a novel drug approved for [antianginal therapy]. The study aims to understand the mechanism of action of ranolazine and its potential role in treating various [cardiac arrhythmias]. The research examines the effects of ranolazine on [multiple ionic currents in cardiac cells] that contribute to the generation of the action potential.

Ranolazine Shows Promise in Treating Cardiac Arrhythmias

The study found that [ranolazine can modify multiple ionic currents involved in cardiac arrhythmias]. This suggests that [ranolazine might be effective in treating different types of arrhythmias]. Additionally, [ranolazine has a favorable safety profile with few side effects]. These findings suggest that ranolazine could be a valuable addition to the therapeutic arsenal for treating cardiac arrhythmias.

A New Hope for Arrhythmia Treatment

The study highlights the potential of [ranolazine] to offer a new approach to treating cardiac arrhythmias. The findings suggest that [ranolazine's unique mechanism of action] may provide advantages over existing antiarrhythmic drugs. However, further research is needed to confirm the long-term efficacy and safety of ranolazine in treating various arrhythmias. While the desert of arrhythmia research is vast, this study offers a promising oasis, pointing towards new and potentially more effective treatment options.

Dr.Camel's Conclusion

This study delves into the intriguing world of cardiac arrhythmias and explores the potential of ranolazine as a new treatment option. It's like exploring the hidden depths of a desert oasis, uncovering new secrets and promising solutions. While more research is needed, this study offers hope for a more effective and well-tolerated treatment for those struggling with cardiac arrhythmias.

Date :
  1. Date Completed 2010-11-22
  2. Date Revised 2022-03-25
Further Info :

Pubmed ID

19898287

DOI: Digital Object Identifier

10.3909/ricm10S10006

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・Side Effects of ranolazine
SNS
PICO Info
in preparation
Languages

English

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