Paper Details 
Original Abstract of the Article :
Chronic myeloid leukemia (CML) is characterized by a Philadelphia chromosome which contains an oncogene, bcr-abl. This oncogene encodes a tyrosine kinase which is constitutively activated. Imatinib, a tyrosine kinase inhibitor (TKI), has been widely used in the treatment of CML. Dasatinib and niloti...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761170/

データ提供:米国国立医学図書館(NLM)

Severe Toxicity of Imatinib: A Case Study and Review of Skin Toxicities Associated with Tyrosine Kinase Inhibitors

Welcome to the fascinating world of oncology research, where we delve into the complexities of treating chronic myeloid leukemia (CML). This case report, like a captivating story told around a desert campfire, explores the severe toxicities associated with imatinib, a tyrosine kinase inhibitor (TKI) commonly used for CML. The authors, like skilled storytellers, present a case of a patient who experienced severe skin rash, high fever, and diarrhea as a result of imatinib treatment. They then embark on a comprehensive review of dermatologic toxicities associated with a range of TKIs, providing valuable insights into the management of these adverse effects. This research, like a map guiding us through the intricacies of cancer treatment, sheds light on the potential side effects of TKIs and the importance of careful monitoring and management.

Navigating the Side Effects: A Balancing Act in Cancer Therapy

This research, like a journey through a desert landscape, reveals the complex interplay between cancer treatment and its potential side effects. The authors, like skilled navigators, carefully guide us through the landscape of TKIs, highlighting the importance of recognizing and managing dermatologic toxicities. The study emphasizes the need for vigilance in monitoring patients for skin rash and other adverse events, particularly those who are receiving TKIs. This knowledge, like a precious oasis in the desert, can help clinicians better manage the side effects of TKIs and improve patient outcomes.

Skin Rash and Tyrosine Kinase Inhibitors: A Reminder of the Importance of Vigilance

This study, like a warning sign in the desert, reminds us of the importance of vigilance in monitoring patients who are receiving TKIs. Skin rash is a common side effect, and it's crucial to be aware of the possibility of more severe reactions. The authors, like experienced desert guides, offer valuable insights into the management of these adverse events, including the importance of recognizing warning signs and taking appropriate steps to prevent complications. This research, like a beacon in the night, shines a light on the importance of careful monitoring and management in oncology care.

Dr.Camel's Conclusion

This case report and review, like a desert story shared around a campfire, underscores the importance of understanding the potential side effects of TKIs in cancer treatment. The authors meticulously document a case of severe toxicity and provide a comprehensive overview of dermatologic adverse events associated with various TKIs. This research serves as a valuable resource for clinicians, helping them to navigate the complexities of cancer treatment and ensure the safety and well-being of their patients.
Date :
  1. Date Completed 2010-06-28
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19920908

DOI: Digital Object Identifier

PMC2761170

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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