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The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline.

Author: AmmiratiMario, AndrewsDavid W, AsherAnthony L, BurriStuart H, CobbsCharles S, GasparLaurie E, KalkanisSteven N, KondziolkaDouglas, LinskeyMark E, LoefflerJay S, McDermottMichael, MehtaMinesh P, MikkelsenTom, OlsonJeffrey J, PaleologosNina A, PatchellRoy A, RobinsonPaula D, RykenTimothy C

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study provides recommendations for treating newly diagnosed brain tumors that have spread from other areas of the body. The study suggests that combining stereotactic radiosurgery (SRS) with whole-brain radiation therapy (WBRT) is generally the best approach, especially for patients with good health (KPS score 70 or above) and one to four tumors. The study also suggests that SRS alone may be effective for some patients, but requires close monitoring for recurrence. While both SRS and surgery combined with WBRT are effective, there is limited evidence supporting the use of SRS alone for larger tumors or those causing significant brain swelling. The study also suggests that SRS alone may be as effective as WBRT alone for treating up to three brain tumors.
Paper Details　
Original Abstract of the Article :
Should patients with newly-diagnosed metastatic brain tumors undergo stereotactic radiosurgery (SRS) compared with other treatment modalities? Target population These recommendations apply to adults with newly diagnosed solid brain metastases amenable to SRS; lesions amenable to SRS are typically de...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808519/

データ提供：米国国立医学図書館（NLM）

Stereotactic Radiosurgery for Brain Metastases: A Comprehensive Guide

Brain metastases, the spread of cancer to the brain, are a serious complication for many cancer patients. This study reviews the evidence for stereotactic radiosurgery (SRS), a non-invasive treatment option for brain metastases, and provides evidence-based clinical practice guidelines for its use. The study examines the effectiveness of SRS compared to other treatment modalities, including whole brain radiation therapy (WBRT).

SRS Plus WBRT: A Powerful Combination for Treating Brain Metastases

The study concludes that single-dose SRS combined with WBRT offers a significant survival advantage for patients with brain metastases, particularly those with good performance status (KPS>70). This combination is also superior in terms of local tumor control and maintaining functional status compared to WBRT alone. These findings highlight the potential of SRS as a key component in a multidisciplinary approach to managing brain metastases.

Understanding the Benefits and Limitations of SRS

The study provides a comprehensive overview of the evidence for SRS and its potential benefits, including improved survival, local tumor control, and preservation of functional status. However, it also emphasizes the importance of careful surveillance to detect local and distant recurrences. For patients treated with SRS alone, regular monitoring is crucial to ensure early identification of any recurrence so that salvage therapy can be initiated promptly.

Dr. Camel's Conclusion

Navigating the complexities of brain metastases requires a multidisciplinary approach that considers individual patient factors and available treatment options. This study provides valuable guidance for healthcare professionals, highlighting the evidence-based benefits of SRS and the need for careful surveillance to ensure optimal outcomes for patients with brain metastases.

Date :
  1. Date Completed 2010-03-24
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

19960227

DOI: Digital Object Identifier

PMC2808519

Related Literature

Article Analysis
・Effective treatment of brain tumors
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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