Safety overview of postmarketing and clinical experience of sodium oxybate (Xyrem): abuse, misuse, dependence, and diversion.

Author: BenowitzNeal L, CarterLawrence P, SwickTodd J, ThorpyMichael J, WangY Grace

Paper Details 
Original Abstract of the Article :
This study reviewed the cumulative postmarketing and clinical safety experience with sodium oxybate (Xyrem), a treatment approved for cataplexy and excessive daytime sleepiness in narcolepsy. Study objectives were to investigate the occurrence of abuse/misuse of sodium oxybate since first market int...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725257/

データ提供:米国国立医学図書館(NLM)

A Journey Through the Landscape of Sodium Oxybate: Understanding Its Safety and Potential for Misuse

Navigating the complex world of medications requires a deep understanding of their safety profiles and potential for misuse. This research examines the postmarketing and clinical safety experience of sodium oxybate, a medication approved for the treatment of cataplexy and excessive daytime sleepiness in narcolepsy. The study sought to investigate the occurrence of abuse and misuse of sodium oxybate since its introduction in 2002. It aimed to classify cases using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for substance abuse and dependence. The study found that while sodium oxybate is an effective treatment for narcolepsy, it has a potential for misuse and dependence.

A Balancing Act: The Benefits and Risks of Sodium Oxybate

This research sheds light on the delicate balance between the benefits and risks of sodium oxybate. While it is an effective treatment for narcolepsy, it is important to be aware of its potential for misuse and dependence. The study's findings underscore the need for careful monitoring and appropriate prescribing practices to ensure patient safety and minimize the risk of adverse outcomes.

A Reminder of Responsible Medication Use

This study serves as a reminder of the importance of responsible medication use. It emphasizes the need for a comprehensive understanding of the potential risks and benefits associated with any medication, including sodium oxybate. It is crucial for healthcare professionals to provide patients with clear and accurate information about their medications to promote informed decision-making and enhance patient safety.

Dr.Camel's Conclusion

Just like a camel carefully navigates its way through the desert, healthcare professionals must navigate the complex landscape of medications with care and attention. This research provides valuable insights into the safety and potential for misuse of sodium oxybate, reminding us of the importance of responsible medication use and the need for vigilance in ensuring patient safety.

Date :
  1. Date Completed 2010-01-06
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

19968016

DOI: Digital Object Identifier

PMC2725257

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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