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Effect of the long-term administration of nebivolol on clinical symptoms, exercise capacity and left ventricular function in patients with heart failure and preserved left ventricular ejection fraction: background, aims and design of the ELANDD study.

Author: BöhmMichael, ConraadsViviane, De KeulenaerGilles W, Dei CasLivio, HuysseLieven, KampOtto, MetraMarco, PieskeBurkert, VardasPanos E, ZamoranoJosé

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A multicenter trial is underway to assess the long-term effects of nebivolol compared to placebo in patients with heart failure and preserved left ventricular ejection fraction. The primary endpoint is change in 6-minute walk test distance.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The SENIORS trial demonstrated that nebivolol has beneficial effects in patients with heart failure. However, the role of beta-blocker therapy in patients with heart failure and preserved left ventricular ejection fraction (HFPEF) is still unsettled. OBJECTIVE: To assess the long-term e...See full text at original site
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引用元：
https://doi.org/10.1007/s00392-009-0098-x

データ提供：米国国立医学図書館（NLM）

Nebivolol for Heart Failure: A Long-Term Journey

Heart failure, a condition where the heart can't pump blood effectively, is like a desert journey where the traveler struggles to keep up with the demands of the path. This study examines the long-term effects of nebivolol, a beta-blocker medication, on patients with heart failure and preserved left ventricular ejection fraction (HFPEF). The researchers aimed to assess the impact of nebivolol on clinical symptoms, exercise capacity, and left ventricular function in patients with HFPEF.

Nebivolol's Potential: A Beacon of Hope in Heart Failure

The study, known as ELANDD, is designed to evaluate the long-term effectiveness of nebivolol in improving the lives of patients with HFPEF. It's like setting out on a long journey across the desert, seeking a safe and effective path to manage heart failure. The primary endpoint of the study is to measure the change in exercise capacity, a key indicator of overall health and function in patients with HFPEF.

Heart Failure Management: A Multifaceted Approach

This study highlights the importance of finding effective treatments for heart failure, a condition that affects millions worldwide. It's like searching for a sustainable oasis in a vast desert, providing relief and support for those struggling with this challenging condition. The research aims to provide valuable insights into the role of nebivolol in the long-term management of HFPEF, potentially leading to improved treatment strategies and better outcomes for patients.

Dr. Camel's Conclusion

This study is a beacon of hope in the desert of heart failure, seeking to explore the long-term potential of nebivolol for improving the lives of patients with HFPEF. By understanding the impact of this medication on various aspects of heart function, we can strive to create a more effective and compassionate approach to managing this challenging condition.
Date :
  1. Date Completed 2010-05-03
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20039172

DOI: Digital Object Identifier

10.1007/s00392-009-0098-x

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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