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Diltiazem (2%) versus glyceryl trinitrate cream (0.2%) in the management of chronic anal fissure.

Author: HashmiFazila, SiddiquiFaisal Ghani

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Both topical 0.2% glycerl trinitrate (GTN) and topical 2% diltiazem (DTZ) are effective in managing chronic anal fissure, but diltiazem has fewer side effects, better wound healing, and lower recurrence rates. The study found that while both treatments were effective, diltiazem was associated with a statistically significant improvement in wound healing and a reduction in headaches.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To assess and compare the effectiveness of topical 0.2% glycerl trinitrate (GTN) and topical 2% diltiazem (DTZ), in the management of chronic anal fissure. STUDY DESIGN: Comparative, descriptive study. PLACE AND DURATION OF STUDY: Department of Surgery, Liaquat University of Medical and...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/20042150

データ提供：米国国立医学図書館（NLM）

Diltiazem vs. Glyceryl Trinitrate Cream for Chronic Anal Fissure

The treatment of chronic anal fissure is a challenging journey, akin to navigating the treacherous dunes of a desert. This study compared the effectiveness of two topical medications, diltiazem and glyceryl trinitrate (GTN), in managing this condition. The researchers found that both medications were effective in improving symptoms and wound healing. However, diltiazem showed a statistically significant advantage in terms of wound healing and reduced side effects, particularly headaches. This suggests that diltiazem might be a preferable treatment option due to its potentially better healing response and fewer side effects.

Diltiazem: A Potential Advantage in Treating Chronic Anal Fissure

The study revealed that diltiazem demonstrated a statistically significant improvement in wound healing compared to GTN. Furthermore, diltiazem was associated with fewer side effects, particularly headaches. While both medications were effective in treating chronic anal fissure, diltiazem's superior healing response and reduced side effects make it a potentially better option for managing this condition.

Chronic Anal Fissure: Understanding the Condition

Chronic anal fissure is a painful condition caused by a tear in the lining of the anus. This study provides valuable insights into the treatment options for this condition, highlighting the potential benefits of diltiazem over GTN. Individuals experiencing symptoms of chronic anal fissure should consult a doctor for proper diagnosis and treatment.

Dr. Camel's Conclusion

This study provides valuable insights into the treatment options for chronic anal fissure. While both diltiazem and GTN are effective, diltiazem may offer a superior healing response and fewer side effects. As a wise camel navigating the vast desert of medical knowledge, I recommend consulting a doctor for personalized advice and treatment tailored to your specific needs.

Date :
  1. Date Completed 2010-04-02
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

20042150

DOI: Digital Object Identifier

12.2009/JCPSP.750753

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English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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