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Thiopurine maintenance therapy for ulcerative colitis: the clinical significance of monitoring 6-thioguanine nucleotide.

Author: AbeJinrou, AraiOsamu, HanaiHiroyuki, HosodaYoshisuke, IidaTakayuki, IkeyaKentarou, KageokaMasanobu, KubotaTakahiro, MaruyamaYasuhiko, MiwaIchita, OohataAkihiko, TakeuchiKen, WatanabeFumitoshi, YoshirouSatou

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Pharmacogenetic guidance of 6-mercaptopurine dose is necessary due to the role of thiopurine methyltransferase polymorphisms in determining therapeutic efficacy and toxicity.
Paper Details　
Original Abstract of the Article :
6-Mercaptopurine (6-MP) is an effective maintenance medication in patients with ulcerative colitis (UC), but toxic effects like myelosuppression limit its clinical benefit. In the blood, 6-thioguanine (6-TGN) is formed from 6-MP and mediates the therapeutic efficacy and most of the toxicities of 6-M...See full text at original site
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引用元：
https://doi.org/10.1002/ibd.21190

データ提供：米国国立医学図書館（NLM）

A Tailored Approach to Thiopurine Therapy: The Significance of 6-Thioguanine Nucleotide Monitoring

Thiopurines are effective drugs for maintaining remission in patients with ulcerative colitis (UC), but their use can be limited by potential toxicities like myelosuppression. This research emphasizes the importance of monitoring 6-thioguanine nucleotide (6-TGN) levels in the blood to optimize thiopurine therapy. The authors point out that 6-TGN, a metabolite of 6-mercaptopurine (6-MP), is responsible for both the therapeutic benefits and toxicities of the drug. Importantly, the level of 6-TGN is influenced by thiopurine methyltransferase (TPMT) activity, which varies among individuals. This finding underscores the need for personalized dosing strategies based on TPMT status.

Personalized Medicine: Tailoring Thiopurine Therapy for Ulcerative Colitis

The research highlights the critical role of personalized medicine in managing ulcerative colitis. Monitoring 6-TGN levels, a key metabolite of thiopurine medications, allows for individualized dosing strategies based on an individual's TPMT activity. This approach ensures that patients receive the optimal therapeutic benefit while minimizing the risk of side effects.

Navigating the Desert of Ulcerative Colitis Management

This study emphasizes the importance of individualizing treatment approaches for ulcerative colitis. Just as a desert traveler adapts their journey based on the terrain, tailoring thiopurine therapy based on 6-TGN levels can help patients navigate their condition effectively. By understanding individual variations in TPMT activity, we can optimize treatment and improve outcomes for patients with ulcerative colitis.

Dr. Camel's Conclusion

This research reveals the importance of personalized medicine in managing ulcerative colitis. Monitoring 6-TGN levels and taking into account TPMT activity allows for individualized dosing strategies, maximizing therapeutic benefits while minimizing potential risks. It's like finding the perfect oasis, tailored to the specific needs of each traveler.

Date :
  1. Date Completed 2010-11-15
  2. Date Revised 2018-09-13
Further Info :

Pubmed ID

20049951

DOI: Digital Object Identifier

10.1002/ibd.21190

SNS
PICO Info
in preparation
Languages

English

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