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A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors.

Author: Delviks-FrankenberryKrista A, NikolenkoGalina N, PathakVinay K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.

Overview

Mutations in the connection subdomain (CN) and RNase H domain of HIV-1 reverse transcriptase (RT) can confer dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs). This study found that these mutations reduce RNase H cleavage, which may allow more time for NNRTIs to dissociate from RT, resulting in resistance.
Paper Details　
Original Abstract of the Article :
Recently, mutations in the connection subdomain (CN) and RNase H domain of HIV-1 reverse transcriptase (RT) were observed to exhibit dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs). To elucidate the mechanism by which CN and RH mutations confer res...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863829/

データ提供：米国国立医学図書館（NLM）

Dual Resistance to HIV-1 Reverse Transcriptase Inhibitors: A Camel's Perspective

The desert of HIV-1 infection presents a daunting landscape, with the virus constantly evolving and adapting to treatment. This research investigates a novel mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs). The authors explore the role of mutations in the connection subdomain (CN) and RNase H domain of HIV-1 reverse transcriptase (RT), highlighting their ability to confer resistance to both classes of inhibitors.

Unraveling the Secrets of Resistance: A Journey Through HIV-1 Evolution

This research sheds light on the intricate mechanisms of resistance to antiretroviral therapy in HIV-1 infection. The authors uncover a novel mechanism by which mutations in the RT can confer resistance to both NRTIs and NNRTIs, highlighting the virus's remarkable ability to adapt and evade treatment. It's like discovering a hidden pathway in the desert, revealing new strategies for survival and adaptation.

Navigating the Desert of HIV-1 Resistance: Towards Effective Treatment

This study underscores the importance of understanding the mechanisms of drug resistance in HIV-1 infection. It's like mapping a vast desert, identifying potential obstacles and finding new pathways to overcome them. By gaining a deeper understanding of resistance mechanisms, we can develop more effective treatment strategies and combat the challenges posed by evolving viral populations.

Dr. Camel's Conclusion

This research offers valuable insights into the dynamic interplay between HIV-1 and antiretroviral therapy. It's like uncovering a hidden oasis in the desert of HIV-1 resistance, providing a new perspective on the virus's ability to adapt and evade treatment. By understanding these complex mechanisms, we can develop more effective treatment strategies and continue our journey toward a world free from HIV-1 infection.

Date :
  1. Date Completed 2010-05-04
  2. Date Revised 2019-10-08
Further Info :

Pubmed ID

20219933

DOI: Digital Object Identifier

PMC2863829

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Languages

English

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