[Direct renin inhibitor aliskiren in the treatment of cardiovascular and renal diseases].

Author: HorkýKarel

Paper Details 
Original Abstract of the Article :
The role of renin-angiotensin-aldosterone system (RAAS) in regulating the volume and composition of extracellular fluid, blood pressure (BP) as well as onset and progression of cardiovascular and renal diseases has been studied for more than 150 years. The compounds that block the vital stages of th...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/20329582

データ提供:米国国立医学図書館(NLM)

Aliskiren: A Direct Renin Inhibitor for Cardiovascular and Renal Diseases

This research explores the potential of [aliskiren], a [direct renin inhibitor], in the treatment of [cardiovascular and renal diseases]. The study highlights the role of the [renin-angiotensin-aldosterone system (RAAS)] in regulating [blood pressure (BP)] and its involvement in the [onset and progression] of [cardiovascular and renal diseases]. The research emphasizes the advantages of aliskiren over existing [RAAS blockers] in terms of its [direct action] on the [renin-angiotensin cascade] and its potential to [reduce BP] and [protect organs] in patients with [hypertension], [heart failure], and [diabetic nephropathy].

Aliskiren: A New Era in RAAS Blockade

The research suggests that aliskiren, as a [direct renin inhibitor], offers a more targeted and potentially more effective approach to [RAAS blockade] compared to existing [ACE inhibitors (ACEIs)], [AT1-receptor blockers (ARBs)], and [aldosterone receptor antagonists]. The clinical studies cited show that aliskiren effectively [reduces BP] and demonstrates [organoprotective properties] in various cardiovascular and renal conditions.

Aliskiren: A Promising Tool for Preventing Cardiovascular and Renal Complications

This research highlights the potential of aliskiren to [reduce the risk] of developing [cardiovascular and renal diseases] and to slow the progression of these conditions. Its [organoprotective properties] and [favorable safety profile] make it a valuable tool in [preventing complications] and [improving outcomes] for patients with [cardiovascular and renal conditions].

Dr. Camel's Conclusion

This research, like a refreshing oasis in the arid landscape of cardiovascular and renal disease treatment, offers a promising new tool for combatting these conditions. Aliskiren, with its targeted action and potential for organ protection, could significantly improve the lives of individuals with hypertension, heart failure, and diabetic nephropathy. It's a reminder that advancements in medicine continue to offer hope in the fight against these complex diseases.

Date :
  1. Date Completed 2010-04-20
  2. Date Revised 2012-11-15
Further Info :

Pubmed ID

20329582

DOI: Digital Object Identifier

20329582

Related Literature

SNS
PICO Info
in preparation
Languages

Czech

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