A comparison of the effects of penicillamine, trientine, and trithiomolybdate on [35S]-labeled metallothionein in vitro; implications for Wilson's disease therapy.

Author: MasonJ, McQuaidA

Paper Details 
Original Abstract of the Article :
The synthesis of radiolabeled metallothionein was induced in rats in vivo by the injection of CuSO4 and [35S]-cysteine. Treatment of "cold" rat liver cytosol "spiked" with purified [35S] metallothionein with Penicillamine and Trientine showed that even at relatively high concentrations (up to 50 mg/...See full text at original site
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引用元:
https://doi.org/10.1016/0162-0134(91)80002-y

データ提供:米国国立医学図書館(NLM)

Wilson's Disease: A Look at Different Therapies

Wilson's disease, a rare genetic disorder affecting copper metabolism, requires effective treatment to prevent severe complications. This research compares the effects of three different medications: penicillamine, trientine, and trithiomolybdate, on copper removal in the context of Wilson's disease.

Trithiomolybdate Shows Potential for Copper Removal

The study found that trithiomolybdate effectively removes copper from metallothionein, a protein involved in copper storage. This contrasts with penicillamine and trientine, which did not show a similar effect. These results suggest that trithiomolybdate might offer a more rational therapeutic option for Wilson's disease patients, potentially leading to better management of the condition.

New Hope for Treating Wilson's Disease

The study highlights the need for further investigation of trithiomolybdate as a potential treatment for Wilson's disease. Its unique mechanism of action in removing copper from metallothionein offers a promising avenue for improving treatment outcomes for individuals with this challenging disorder. Consulting with a specialist is crucial for proper diagnosis and treatment of Wilson's disease.

Dr. Camel's Conclusion

The study's findings are particularly interesting as they suggest new avenues for treatment of Wilson's disease. Just like a camel adapts to survive in the harsh desert environment, finding innovative therapies for rare diseases is essential for patient well-being. This research underscores the importance of continuous scientific exploration to improve the lives of individuals with debilitating conditions.

Date :
  1. Date Completed 1991-06-26
  2. Date Revised 2019-09-07
Further Info :

Pubmed ID

2033396

DOI: Digital Object Identifier

10.1016/0162-0134(91)80002-y

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SNS
PICO Info
in preparation
Languages

English

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