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Induction of fluconazole metabolism by rifampin: in vivo study in humans.

Author: ApseloffG, GardnerM J, GerberN, HenryE B, HilligossD M, InskeepP B, LazarJ D

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Rifampin was found to induce the metabolism of fluconazole, leading to a reduction in its area under the curve (AUC) and elimination half-life. This suggests the need for dose adjustments when co-administering these drugs.
Paper Details　
Original Abstract of the Article :
The effects of rifampin on the pharmacokinetics of fluconazole were analyzed in an open-label, placebo-controlled, parallel study. Sixteen healthy male volunteers, randomized into two groups, received 200 mg of oral fluconazole on days 1 and 22. On days 8 through 27, group I received oral rifampin, ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1002/j.1552-4604.1991.tb03718.x

データ提供：米国国立医学図書館（NLM）

Fluconazole Metabolism: The Impact of Rifampin

The field of [pharmacokinetics] is essential for understanding how medications work in the body. This study investigates the effects of [rifampin] on the metabolism of [fluconazole], an antifungal medication. The researchers conducted a [placebo-controlled, parallel study] to examine how rifampin influences the levels of fluconazole in the blood. The aim was to determine if rifampin alters the way the body processes fluconazole.

Rifampin's Influence on Fluconazole Metabolism: An Inducer's Role

The study revealed that rifampin significantly increased the metabolism of fluconazole, leading to lower levels of the medication in the blood. This finding suggests that rifampin can act as an inducer of fluconazole metabolism, potentially affecting its therapeutic efficacy.

Medication Interactions: Navigating the Complexities of Drug Metabolism

This study highlights the importance of considering potential drug interactions. The findings underscore the need for healthcare professionals to be aware of how medications can influence each other's metabolism, potentially impacting their effectiveness. This knowledge is crucial for optimizing medication regimens and ensuring patient safety.

Dr. Camel's Conclusion

The world of drug interactions can be as complex as the shifting sands of a desert. This study reminds us that medications don't always play well together. The findings highlight the importance of understanding how medications can influence each other's metabolism, urging us to navigate the complexities of drug interactions with caution.

Date :
  1. Date Completed 1991-06-28
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

2037709

DOI: Digital Object Identifier

10.1002/j.1552-4604.1991.tb03718.x

Related Literature

Article Analysis
・Effects of rifampin
SNS
PICO Info
in preparation
Languages

English

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