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Changes in the levels of some acute-phase proteins in human immunodeficiency virus-1 infected patients, following interleukin-2 treatment.

Author: BarbaiV H, BánhegyiD, FeyE, FüstG, SzlávikJ, UjhelyiE, VargaL, VietoriszI

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the effects of interleukin (IL)-2 administration on acute-phase protein (APP) levels in HIV-infected patients. IL-2 administration rapidly elevated CRP and D-dimer levels, but these returned to baseline within a few weeks.
Paper Details　
Original Abstract of the Article :
Intermittent interleukin (IL)-2 administration to human immunodeficiency virus (HIV)-1 infected patients is well documented and generally used, but there is limited information about the changes of acute-phase protein (APP) levels in response to this treatment. Fifteen patients undergoing highly act...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940158/

データ提供：米国国立医学図書館（NLM）

Interleukin-2: A Potential Tool for HIV Treatment

This study examines the impact of interleukin-2 (IL-2) treatment on the levels of acute-phase proteins (APPs) in HIV-1 infected patients. The researchers explore the potential of IL-2 to boost the immune system and increase CD4+ cell counts in patients undergoing highly active antiretroviral therapy (HAART). They analyze the changes in APP levels in response to IL-2 treatment and investigate their correlation with changes in CD4+ cell counts.

IL-2: A Potential Booster for Immune Function

The study reveals that IL-2 administration leads to a rapid increase in CRP and D-dimer levels, two major APPs. These findings suggest that IL-2 treatment may stimulate the immune system, leading to an inflammatory response. The positive correlation observed between changes in CRP levels and CD4+ cell counts indicates a potential link between IL-2-induced inflammation and immune recovery.

Understanding HIV Treatment

HIV infection is a complex and chronic condition requiring ongoing medical management. Treatment options have evolved significantly over the years, and HAART has proven highly effective in controlling the virus. This study highlights the potential of IL-2 as an adjunct therapy in improving immune function and increasing CD4+ cell counts in patients undergoing HAART.

Dr.Camel's Conclusion

This study sheds light on the potential role of IL-2 in HIV treatment. The study's findings suggest that IL-2 administration may stimulate the immune system, leading to an inflammatory response and a potential increase in CD4+ cell counts. Further research is needed to fully understand the mechanisms involved and to explore the optimal use of IL-2 in HIV treatment.

Date :
  1. Date Completed 2010-08-02
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20408859

DOI: Digital Object Identifier

PMC2940158

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Languages

English

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