Role of aspirin in tuberculous meningitis: a randomized open label placebo controlled trial.

Author: KalitaJ, MisraU K, NairP P

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To evaluate the efficacy and safety of aspirin in preventing stroke and mortality in tuberculous meningitis (TBM). METHODS: Patients with TBM diagnosed on the basis of clinical, MRI and cerebrospinal fluid (CSF) criteria were randomized into aspirin 150 mg daily or placebo. All the patie...See full text at original site
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引用元:
https://doi.org/10.1016/j.jns.2010.03.025

データ提供:米国国立医学図書館(NLM)

Exploring the Role of Aspirin in Tuberculous Meningitis

Tuberculous meningitis (TBM), a serious infection of the brain and meninges, can be life-threatening. This study investigates the efficacy and safety of aspirin in preventing stroke and mortality in patients with TBM. The authors conducted a randomized, open-label, placebo-controlled trial to assess the potential benefits of aspirin in managing TBM. The study design involves randomizing patients to receive either aspirin or placebo, while all patients receive standard antitubercular treatment. The primary outcome measures include MRI-proven stroke at 3 months and mortality.

Aspirin Offers Potential Benefits for Tuberculous Meningitis

The study demonstrates that aspirin resulted in a significantly reduced 3-month mortality rate in patients with TBM, compared to the placebo group. This finding suggests that aspirin may play a role in improving outcomes for patients with TBM. This is a significant discovery, like finding a hidden spring in the desert, offering a potential source of relief and hope for those suffering from this debilitating condition.

Navigating the Complexities of Tuberculous Meningitis

Tuberculous meningitis is a serious and challenging condition that requires careful management and treatment. This study highlights the potential benefits of aspirin in managing TBM, but it also underscores the need for further research to fully understand its role and optimal use. This is a journey through the desert of TBM, where finding effective treatment options and navigating the complexities of this condition is critical for improving patient outcomes.

Dr.Camel's Conclusion

This study presents compelling evidence for the potential benefits of aspirin in managing tuberculous meningitis. The findings suggest that aspirin may offer a valuable tool for improving outcomes and reducing mortality in patients with TBM. This is a significant step forward in our understanding of TBM management, providing hope for improved outcomes for those suffering from this challenging condition.

Date :
  1. Date Completed 2010-08-12
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

20421121

DOI: Digital Object Identifier

10.1016/j.jns.2010.03.025

Related Literature

SNS
PICO Info
in preparation
Languages

English

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