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Implications of new monoclonal antibodies and the crystal structure of the TSH receptor for the treatment and management of thyroid diseases.
Author: FurmaniakJadwiga, Rees SmithBernard, SandersJane
Original Abstract of the Article :
Autoantibodies to the thyroid-stimulating hormone receptor (TSHR) cause the hyperthyroidism of Graves' disease and contribute to Graves' eye signs. Human monoclonal TSHR autoantibodies prepared from patients' lymphocytes have important clinical applications in terms of their ability to stimulate TSH...See full text at original site
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引用元:
https://doi.org/10.2217/17520363.2.6.567
データ提供:米国国立医学図書館(NLM)
Unlocking the Secrets of the TSH Receptor: New Avenues for Thyroid Disease Treatment
The [thyroid-stimulating hormone receptor (TSHR)] is a key player in [thyroid function] and the development of [thyroid diseases]. This research explores the potential of [monoclonal antibodies] targeting the [TSHR] for the treatment and management of [Graves' disease and Graves' eye disease]. The researchers discuss the clinical applications of [human monoclonal TSHR autoantibodies] and the potential of [TSHR-antagonist monoclonal antibodies] to treat [Graves' eye disease]. The recent determination of the [crystal structure] of the [TSHR] complex with a [monoclonal thyroid-stimulating autoantibody] provides valuable insights into the receptor's structure and function, paving the way for the development of [new therapeutic strategies].
A New Era of Targeted Thyroid Therapies
The study's findings highlight the potential of [monoclonal antibodies] as a promising new approach for treating [thyroid diseases]. The researchers' discussion of [human monoclonal TSHR autoantibodies] and [TSHR-antagonist monoclonal antibodies] suggests that these therapies could offer [effective and targeted treatments] for various thyroid conditions. The availability of the [TSHR crystal structure] provides a valuable tool for developing [new therapies] that can specifically target the receptor, opening up exciting possibilities for [precision medicine] in thyroid care.
The Promise of Precision Medicine in Thyroid Care
This research highlights the transformative potential of [precision medicine] in the field of [thyroid care]. The study's findings suggest that [understanding the structure and function of the TSH receptor] is crucial for developing [effective and targeted therapies] for [thyroid diseases]. The researchers' work paves the way for a future where [precision medicine] can provide personalized treatment options, optimizing outcomes and improving the lives of patients with thyroid conditions.
Dr.Camel's Conclusion
Just like the desert oasis provides essential water for thirsty travelers, the TSH receptor plays a crucial role in regulating thyroid function. This research sheds light on the potential of targeted therapies to restore balance and improve the lives of those with thyroid disorders.
Date :
- Date Completed 2010-06-10
- Date Revised 2010-05-18
Further Info :
Related Literature
English
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