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Value of allogeneic versus autologous stem cell transplantation and chemotherapy in patients with myelodysplastic syndromes and secondary acute myeloid leukemia. Final results of a prospective randomized European Intergroup Trial.

Author: AmadoriSergio, BelhabriAmin, BiersackHarald, DelforgeMichel, FerrantAugustin, GratwohlAlois, HagemeijerAnne, Hellström-LindbergEva, JansenJoop H, KobbeGuido, KovacsovicsTibor, MarieJean-Pierre, MuusPetra, OssenkoppeleGert, SchoutenHarry C, SelleslagDominik, SuciuStefan, WijermansPierre, WillemzeRoel, de WitteTheo

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This article discusses allogeneic stem cell transplantation, post-remission chemotherapy, and autologous stem cell transplantation as treatment options for patients with advanced or transformed myelodysplastic syndromes.
Paper Details　
Original Abstract of the Article :
Allogeneic stem cell transplantation is usually considered the only curative treatment option for patients with advanced or transformed myelodysplastic syndromes in complete remission, but post-remission chemotherapy and autologous stem cell transplantation are potential alternatives, especially in ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948102/

データ提供：米国国立医学図書館（NLM）

Myelodysplastic Syndromes (MDS): A Shifting Sands of Blood Disorders

Myelodysplastic syndromes (MDS), a group of blood disorders, are like shifting sands in the desert, affecting the production of blood cells. This research investigates the effectiveness of different treatment options for MDS, exploring the potential of stem cell transplantation, a procedure like creating a stable oasis in the desert, to restore healthy blood production.

Exploring the Sands of MDS Treatment

The researchers conducted a randomized clinical trial, a rigorous research method like carefully studying the effects of different types of sand dunes on the desert landscape. They compared the outcomes of allogeneic stem cell transplantation and autologous stem cell transplantation, along with chemotherapy, seeking to identify the most effective approach for managing MDS.

Navigating the Desert of Blood Disorders

This research highlights the importance of finding the right treatment for MDS, a condition that can be quite challenging. It emphasizes the need for personalized care and a careful consideration of the potential benefits and risks of various treatment options.

Dr. Camel's Conclusion

This research provides valuable insights into the treatment of MDS, offering a roadmap for navigating the shifting sands of this complex blood disorder. It emphasizes the importance of individualizing treatment plans and exploring different options to improve the outcomes for patients.

Date :
  1. Date Completed 2011-02-23
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20494931

DOI: Digital Object Identifier

PMC2948102

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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