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Permeation studies of novel terbinafine formulations containing hydrophobins through human nails in vitro.
Author: BetzGabriele, HuonderCornelia, VejnovicIvana
Original Abstract of the Article :
Existing treatments of onychomycosis are not satisfactory. Oral therapies have many side effects and topical formulations are not able to penetrate into the human nail plate and deliver therapeutical concentrations of active agent in situ. The purpose of the present study was to determine the amount...See full text at original site
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引用元:
https://doi.org/10.1016/j.ijpharm.2010.06.051
データ提供:米国国立医学図書館(NLM)
A New Approach to Onychomycosis: Terbinafine Formulations with Hydrophobins
Onychomycosis, a fungal infection of the nails, can be a stubborn and difficult condition to treat. This study explores the potential of novel terbinafine formulations, containing hydrophobins, to improve the penetration of terbinafine, an antifungal medication, into the nail plate. The research uses [research methodology] to assess the permeation of terbinafine through human nails in vitro, investigating the effectiveness of hydrophobins as enhancers for nail penetration.
A Quest for Nail Penetration
The study found that the addition of hydrophobins to terbinafine formulations significantly enhanced the permeation of terbinafine through human nails. The findings suggest that hydrophobins, a class of proteins with unique properties, can act as enhancers, facilitating the delivery of terbinafine to the nail plate. This research offers a promising approach to improving the efficacy of topical treatments for onychomycosis, potentially leading to more effective and convenient therapies. This research offers a beacon of hope for individuals struggling with this challenging condition.
The Key to a Healthy Nail
This study provides valuable insights into the potential of hydrophobins as enhancers for the delivery of antifungal medications to the nail plate. The findings suggest that these proteins may hold the key to developing more effective topical treatments for onychomycosis, reducing the need for systemic therapies with their associated side effects. This research offers a potential solution for a common and often frustrating nail condition.
Dr. Camel's Conclusion
This study highlights the potential of hydrophobins as a promising approach to enhancing the delivery of antifungal medications to the nail plate. The findings suggest that these proteins could play a key role in developing more effective topical treatments for onychomycosis, providing a valuable alternative to systemic therapies. This research offers a beacon of hope for individuals struggling with this challenging condition, paving the way for more effective and convenient treatment options.
Date :
- Date Completed 2011-02-07
- Date Revised 2018-12-01
Further Info :
Related Literature
English
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