[Therapeutic drug monitoring of 6-thioguanine nucleotides in inflammatory bowel disease: interest and limits].

Author: , BoulieuRoselyne, FonroseXavier, JourdilNicole, Stanke-LabesqueFrançoise

Paper Details 
Original Abstract of the Article :
Azathioprine, 6-mercaptopurine, and 6-thioguanine are immunosuppressive drugs indicated in the prevention of graft rejection, and treatment of auto-immune disease or inflammatory bowel disease. Their anti-nucleotidic properties are also used for the treatment of acute leukaemia. Their metabolism inv...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/20699068

データ提供:米国国立医学図書館(NLM)

Therapeutic Drug Monitoring of 6-Thioguanine Nucleotides in Inflammatory Bowel Disease: A Balancing Act

The management of inflammatory bowel disease (IBD) is a delicate balancing act, much like navigating a desert landscape where every step must be carefully considered. This research explores the use of therapeutic drug monitoring (TDM) to optimize the treatment of IBD with thiopurine drugs, medications that can effectively manage the disease but also carry potential side effects. The authors delve into the role of TDM in ensuring appropriate dosing and minimizing the risk of adverse effects, providing a valuable tool for clinicians and patients alike.

The Importance of Therapeutic Drug Monitoring in IBD

This research, like a carefully constructed map of a desert region, highlights the importance of TDM in managing IBD patients treated with thiopurine drugs. The authors emphasize the need to balance the therapeutic benefits of these medications with the potential for toxicity. TDM can help clinicians tailor dosage to individual patients, ensuring they receive the optimal therapeutic effect while minimizing the risk of side effects. This approach, like a cool desert breeze, can offer a more comfortable and effective treatment experience for patients.

Navigating IBD Treatment with TDM

As you navigate the desert of IBD management, remember that open communication with your doctor is essential. Discuss your concerns, potential treatment options, and any side effects you experience. Like a wise camel, be proactive in managing your health and seeking professional guidance when needed. TDM can be a valuable tool in this journey, helping you and your doctor make informed decisions about your treatment and ensure the best possible outcome.

Dr.Camel's Conclusion

This research emphasizes the vital role of TDM in optimizing thiopurine therapy for IBD patients. By carefully monitoring drug levels and adjusting dosages accordingly, clinicians can ensure that patients receive the full benefits of these medications while minimizing the risk of adverse effects. It's a reminder that even in the vast and complex landscape of IBD management, we have tools and strategies to help patients navigate this challenging journey and achieve optimal health.

Date :
  1. Date Completed 2010-10-25
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

20699068

DOI: Digital Object Identifier

th101844

Related Literature

SNS
PICO Info
in preparation
Languages

French

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