Evaluation of HIV protease and nucleoside reverse transcriptase inhibitors on proliferation, necrosis, apoptosis in intestinal epithelial cells and electrolyte and water transport and epithelial barrier function in mice.

Author: AguiarCarolina V, Braga NetoManuel B, BritoGerly A C, GuerrantRichard L, LimaAldo A M, MacielJamilly G, OliveiraBruna M C, OriáReinaldo B, SevillejaJesus E, WarrenCirle A

Paper Details 
Original Abstract of the Article :
Protease inhibitors (PI's) and reverse transcriptase drugs are important components of highly active antiretroviral therapy (HAART) for treating human acquired immunodeficiency syndrome (AIDS). Long-term clinical therapeutic efficacy and treatment compliance of these agents have been limited by unde...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931456/

データ提供:米国国立医学図書館(NLM)

Investigating the Impact of Antiretroviral Drugs on the Gut

The field of [HIV treatment] is constantly evolving, with the goal of improving patient outcomes and minimizing side effects. This study delves into the [intestinal effects of antiretroviral drugs], a crucial area of research given the prevalence of diarrhea as a common side effect. The authors utilized an [in vivo and in vitro approach] to investigate the effects of selected antiretroviral agents on intestinal health. They observed that these drugs can have a significant impact on the [intestinal epithelium], influencing both [cell proliferation and death]. These findings are important for understanding the [potential complications of HAART] and for developing strategies to mitigate them.

Uncovering the Gut's Response to Antiretroviral Therapy

This research highlights the complex relationship between [antiretroviral drugs] and the [intestinal environment]. By understanding how these drugs affect the [intestinal epithelium] at the cellular level, we can gain valuable insights into the development of [diarrhea and other gastrointestinal side effects]. This knowledge can inform the development of [personalized treatment plans] that minimize these complications, ultimately improving the quality of life for patients living with HIV.

Navigating the Desert of Side Effects

Just like a camel navigating a vast desert, patients with HIV must navigate the potential side effects of antiretroviral therapy. This research sheds light on the [intestinal impacts of these medications], providing crucial information for [improving patient care and minimizing complications]. By understanding how these drugs affect the [intestinal environment], we can help patients avoid the unwelcome oasis of diarrhea and other gastrointestinal issues, allowing them to journey through their treatment with greater ease.

Dr. Camel's Conclusion

This study is a reminder that while antiretroviral therapy has revolutionized HIV treatment, we must continue to explore the potential side effects of these medications. By understanding the impact of these drugs on the gut, we can pave a smoother path for patients navigating the desert of HIV treatment.

Date :
  1. Date Completed 2010-10-11
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20701796

DOI: Digital Object Identifier

PMC2931456

Related Literature

SNS
PICO Info
in preparation
Languages

English

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