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Reversal of skeletal effects of endocrine treatments in the Intergroup Exemestane Study.

Author: BanksLinda M, BlissJudith M, CawthornSimon J, ColemanRobert E, CoombesR Charles, FoxJohn, GirgisSamia I, KilburnLucy S, PatelAshraf, VrdoljakEduard

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examines the effects of endocrine treatment withdrawal on bone health in patients with breast cancer who were previously treated with tamoxifen or exemestane. The results show that the bone effects of exemestane are reversed after treatment withdrawal.
Paper Details　
Original Abstract of the Article :
The adjuvant use of aromatase inhibitors in breast cancer is associated with adverse effects on bone health. We previously reported a decline in bone mineral density (BMD) following the switch from tamoxifen to exemestane in the Intergroup Exemestane Study (IES). Here we report effects of endocrine ...See full text at original site
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引用元：
https://doi.org/10.1007/s10549-010-1121-7

データ提供：米国国立医学図書館（NLM）

Endocrine Treatment for Breast Cancer: Navigating the Shifting Sands of Bone Health

This study investigates the impact of endocrine treatments, particularly aromatase inhibitors (AIs), on bone health in breast cancer patients. The research examines the effects of switching from tamoxifen to exemestane on bone mineral density (BMD), bone turnover markers (BTM), and fracture rates. The authors aim to assess the long-term consequences of endocrine treatment withdrawal on bone health, providing valuable insights for managing this potential side effect.

Bone Health: A Vital Consideration in the Journey Through Breast Cancer Treatment

This study emphasizes the importance of monitoring bone health in patients undergoing endocrine treatment for breast cancer. The research reveals that while AIs can be effective in managing the disease, they can also lead to bone loss. The study's findings suggest that the adverse bone effects of exemestane are reversible with treatment withdrawal. This knowledge is critical for tailoring treatment strategies and managing bone health effectively in these patients.

Bone Health: A Hidden Dune in the Landscape of Breast Cancer Care

This research, like a compass guiding us through the desert of breast cancer treatment, offers valuable insights into the importance of addressing bone health. It highlights the need for ongoing monitoring of BMD and BTM, especially in patients receiving AIs. The study emphasizes the importance of individualizing treatment strategies to minimize bone loss and promote overall well-being.

Dr. Camel's Conclusion

This study is a reminder that the desert of breast cancer treatment can hold hidden dunes, such as the impact of endocrine treatments on bone health. It provides valuable insights for managing this potential side effect, highlighting the importance of ongoing monitoring and individualized treatment approaches.

Date :
  1. Date Completed 2011-01-31
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

20730486

DOI: Digital Object Identifier

10.1007/s10549-010-1121-7

Related Literature

Article Analysis
・Effects of exemestane
SNS
PICO Info
in preparation
Languages

English

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