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Risk of upper gastrointestinal tract events in risedronate users switched to alendronate.

Author: KouTzuyung D, MasudTahir, RalstonStuart H, SteinbuchMichael, Wick-UrbanBettina

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Switching patients stabilized on risedronate to alendronate was associated with an increased risk of upper gastrointestinal (GI) adverse effects, particularly in patients with a history of GI events (hazard ratio [HR] = 3.18, 95% confidence interval [CI] 2.79-3.63). The increased risk may offset the cost savings of using the generic alendronate formulation.
Paper Details　
Original Abstract of the Article :
Upper gastrointestinal (GI) side effects are a known complication of therapy with oral aminobisphosphonates, but it is currently unclear if bisphosphonate type or formulation influences the risk of developing side effects. Here, we performed a retrospective cohort study to determine if patients who ...See full text at original site
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引用元：
https://doi.org/10.1007/s00223-010-9401-0

データ提供：米国国立医学図書館（NLM）

Switching bisphosphonates: A cautionary tale

Bisphosphonates are often used to treat osteoporosis, a condition that weakens bones. While these medications can be effective, they can sometimes cause side effects, especially in the upper gastrointestinal tract. This study investigates the potential risks associated with switching from risedronate to alendronate, two common bisphosphonates. It's like trying to find the best route through a desert, where each path has its own risks and rewards.

Switching bisphosphonates may increase GI side effects

The study found that switching from risedronate to alendronate is associated with an increased risk of gastrointestinal side effects, especially in patients with a history of GI problems. This information is important for doctors and patients to consider when making treatment decisions, as it highlights the potential downsides of switching bisphosphonates.

Be aware of potential side effects

It's crucial to be aware of the potential side effects of bisphosphonates, especially when switching between medications. Patients should talk to their doctor about any concerns they have and work together to make informed decisions about treatment. Just as a camel carefully chooses its path through the desert to avoid potential hazards, patients should be aware of the potential risks associated with their medications.

Dr.Camel's Conclusion

Switching medications can sometimes feel like navigating a new desert route. This study reminds us that not all paths are created equal! While bisphosphonates can be helpful, it's essential to be mindful of the potential risks, especially when switching medications. By working closely with their doctors, patients can make informed choices about their treatment and navigate the journey towards better health with more confidence.

Date :
  1. Date Completed 2011-01-06
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20803291

DOI: Digital Object Identifier

10.1007/s00223-010-9401-0

Related Literature

Article Analysis
・Side Effects of risedronate
SNS
PICO Info
in preparation
Languages

English

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