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Beneficial effects of angiotensin II receptor blocker, olmesartan, in limiting the cardiotoxic effect of daunorubicin in rats.

Author: AizawaYoshifusa, ArozalWawaimuli, HarimaMeilei, KodamaMakoto, SukumaranVijayakumar, SuzukiKenji, TachikawaHitoshi, ThandavarayanRajarajan A, VeeraveeduPunniyakoti T, WatanabeKenichi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Olmesartan, an angiotensin II receptor blocker (ARB), reduces cardiac toxicity in rats treated with daunorubicin. The results suggest that Ang II and oxidative stress play a role in anthracycline-induced cardiotoxicity.
Paper Details　
Original Abstract of the Article :
The aim was to evaluate the role of the combination of olmesartan, an angiotensin II (Ang II) receptor blocker (ARB), with daunorubicin (DNR) in reducing cardiac toxicity in rats. DNR was administered at a dose of 3 mg/kg/day every other day for 12 days. Olmesartan was administered orally every day ...See full text at original site
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引用元：
https://doi.org/10.3109/10715762.2010.509399

データ提供：米国国立医学図書館（NLM）

Protecting the Heart from Chemotherapy

This research delves into the desert of cardiovascular research to explore the potential of olmesartan, an angiotensin II receptor blocker (ARB), to protect the heart from the damaging effects of chemotherapy. The authors investigated the ability of olmesartan to mitigate the cardiotoxicity of daunorubicin, a chemotherapy drug, in rats. This research is essential for finding ways to protect the heart from the side effects of cancer treatments.

Olmesartan: A Protective Oasis for the Heart

The study found that olmesartan significantly reduced cardiac toxicity in rats receiving daunorubicin. This research offers a promising approach to protecting the heart from the damaging effects of chemotherapy, providing a potential oasis in the desert of chemotherapy side effects. The study highlights the importance of protecting the heart during cancer treatment.

Heart Health During Cancer Treatment

This research is a reminder that even in the face of cancer treatment, it’s essential to protect the heart. It underscores the importance of finding ways to minimize the side effects of chemotherapy and improve the overall health of patients. The potential of olmesartan offers a glimmer of hope for individuals undergoing chemotherapy.

Dr.Camel's Conclusion

This research offers promising evidence for the protective effects of olmesartan in reducing chemotherapy-induced cardiotoxicity. It’s a valuable step towards finding ways to protect the heart during cancer treatment, offering a potential oasis in the desert of treatment side effects.

Date :
  1. Date Completed 2011-01-25
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

20815778

DOI: Digital Object Identifier

10.3109/10715762.2010.509399

Related Literature

Article Analysis
・Effects of daunorubicin
SNS
PICO Info
in preparation
Languages

English

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