Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial.

Author: AshleyElizabeth, AungPyay Phyo, ImwongMallika, KyawMoe Kyaw, LeeSue J, MyintNaing Zaw Htun, NaingArkar Linn, NyoMya Yee, OoAung Pyay Phyo, PheOhn, SmithuisFrank, WhiteNicholas J, WinThein

Paper Details 
Original Abstract of the Article :
Artemisinin-combination therapy (ACT) is recommended as first-line treatment of falciparum malaria throughout the world, and fixed-dose combinations are preferred by WHO; whether a single gametocytocidal dose of primaquine should be added is unknown. We aimed to compare effectiveness of four fixed-d...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947715/

データ提供:米国国立医学図書館(NLM)

Assessing the Effectiveness of Artemisinin Combination Regimens for Uncomplicated Falciparum Malaria

Malaria, a deadly mosquito-borne disease, continues to pose a significant threat to global health. This study delves into the world of antimalarial therapy, evaluating the effectiveness of five different artemisinin combination regimens (ACTs) in treating uncomplicated falciparum malaria. The researchers conducted an open-label randomized trial, enrolling patients with uncomplicated falciparum malaria and randomly assigning them to receive one of the five ACTs. They meticulously monitored patient outcomes, assessing the effectiveness of each regimen and evaluating the impact of adding a single dose of primaquine, a gametocytocidal drug, to the treatment regimen.

Comparing ACTs for Optimal Malaria Treatment

The study's findings provide valuable insights into the effectiveness of different ACTs for treating uncomplicated falciparum malaria. The research highlights the importance of using effective ACTs, particularly those that include a gametocytocidal drug like primaquine, to reduce the risk of malaria transmission.

Combating Malaria Through Effective Treatment

This study offers a comprehensive assessment of different treatment options for uncomplicated falciparum malaria, providing valuable guidance for healthcare professionals. The findings underscore the importance of utilizing effective ACTs to combat malaria and prevent its spread.

Dr.Camel's Conclusion

The fight against malaria requires a multi-faceted approach, including effective treatment and prevention strategies. This study contributes to our understanding of the effectiveness of different treatment options, paving the way for improved patient outcomes and a more robust global response to this debilitating disease.

Date :
  1. Date Completed 2010-10-19
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

20832366

DOI: Digital Object Identifier

PMC2947715

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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