Salicylate pre-treatment attenuates intensity of bronchial and nasal symptoms precipitated by aspirin in aspirin-intolerant patients.

Author: DworskiR, NizankowskaE, SojaJ, SzczeklikA

Paper Details 
Original Abstract of the Article :
Aspirin (ASA) and other non-steroidal anti-inflammatory drugs, which are cyclooxygenase (COX) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while sodium salicylate, hardly active on COX by itself, is well tolerated by these patients. However, salicylate moiety appears to inte...See full text at original site
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引用元:
https://doi.org/10.1111/j.1365-2222.1990.tb02703.x

データ提供:米国国立医学図書館(NLM)

Aspirin Intolerance: A Tale of Two Salicylates

In the world of allergies, aspirin intolerance stands out like a lone cactus in the desert, causing a frustrating reaction in some individuals. This research explores the potential of salicylate pre-treatment, like a protective oasis in the midst of an allergic storm, to attenuate the intensity of bronchial and nasal symptoms triggered by aspirin in aspirin-intolerant patients. The study utilizes a double-blind, placebo-controlled, randomized cross-over design, a rigorous scientific approach akin to carefully navigating a treacherous desert route.

Salicylate Pre-treatment: A Potential Oasis for Aspirin Intolerance

The study reveals that choline magnesium trisalicylate (CMT), a salicylate compound, administered for three days prior to aspirin challenge, significantly diminished the severity and delayed the onset of respiratory symptoms in aspirin-intolerant patients. The effect of CMT, like a refreshing spring in the arid desert, was observed in a reduction of FEV1 fall and nasal symptoms, suggesting a potential protective mechanism against aspirin-induced asthma.

Managing Aspirin Intolerance: A Journey Through the Desert of Allergies

This research offers a glimmer of hope for individuals struggling with aspirin intolerance. While further research is needed to fully understand the mechanisms involved, the findings suggest that salicylate pre-treatment may offer a potential avenue for managing this challenging condition. As with any medication, it's vital to consult with a healthcare professional for proper guidance and treatment options.

Dr. Camel's Conclusion

This research, like a camel seeking respite from the desert's harshness, explores a potential solution for aspirin intolerance. The study's findings suggest that salicylate pre-treatment may offer a valuable tool for managing this allergic condition, providing a beacon of hope for individuals navigating the challenges of aspirin-induced reactions.

Date :
  1. Date Completed 1991-05-14
  2. Date Revised 2019-08-28
Further Info :

Pubmed ID

2083404

DOI: Digital Object Identifier

10.1111/j.1365-2222.1990.tb02703.x

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SNS
PICO Info
in preparation
Languages

English

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