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Salicylate pre-treatment attenuates intensity of bronchial and nasal symptoms precipitated by aspirin in aspirin-intolerant patients.
Author: DworskiR, NizankowskaE, SojaJ, SzczeklikA
Original Abstract of the Article :
Aspirin (ASA) and other non-steroidal anti-inflammatory drugs, which are cyclooxygenase (COX) inhibitors, precipitate asthmatic attacks in ASA-intolerant patients, while sodium salicylate, hardly active on COX by itself, is well tolerated by these patients. However, salicylate moiety appears to inte...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1111/j.1365-2222.1990.tb02703.x
データ提供:米国国立医学図書館(NLM)
Aspirin Intolerance: A Tale of Two Salicylates
In the world of allergies, aspirin intolerance stands out like a lone cactus in the desert, causing a frustrating reaction in some individuals. This research explores the potential of salicylate pre-treatment, like a protective oasis in the midst of an allergic storm, to attenuate the intensity of bronchial and nasal symptoms triggered by aspirin in aspirin-intolerant patients. The study utilizes a double-blind, placebo-controlled, randomized cross-over design, a rigorous scientific approach akin to carefully navigating a treacherous desert route.
Salicylate Pre-treatment: A Potential Oasis for Aspirin Intolerance
The study reveals that choline magnesium trisalicylate (CMT), a salicylate compound, administered for three days prior to aspirin challenge, significantly diminished the severity and delayed the onset of respiratory symptoms in aspirin-intolerant patients. The effect of CMT, like a refreshing spring in the arid desert, was observed in a reduction of FEV1 fall and nasal symptoms, suggesting a potential protective mechanism against aspirin-induced asthma.
Managing Aspirin Intolerance: A Journey Through the Desert of Allergies
This research offers a glimmer of hope for individuals struggling with aspirin intolerance. While further research is needed to fully understand the mechanisms involved, the findings suggest that salicylate pre-treatment may offer a potential avenue for managing this challenging condition. As with any medication, it's vital to consult with a healthcare professional for proper guidance and treatment options.
Dr. Camel's Conclusion
This research, like a camel seeking respite from the desert's harshness, explores a potential solution for aspirin intolerance. The study's findings suggest that salicylate pre-treatment may offer a valuable tool for managing this allergic condition, providing a beacon of hope for individuals navigating the challenges of aspirin-induced reactions.
Date :
- Date Completed 1991-05-14
- Date Revised 2019-08-28
Further Info :
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