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The effects of methylnaltrexone alone and in combination with acutely administered codeine on gastrointestinal and colonic transit in health.

Author: BurtonD D, BusciglioI, CamilleriM, ManabeN, McKinzieS, RaoA S, RyksM, WongB S, ZinsmeisterA R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Methylnaltrexone did not affect gastrointestinal or colonic transit and did not reverse acute codeine-associated delayed gut transit in healthy individuals.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The short-term effects of methylnaltrexone (MNTX), a peripherally acting mu-opioid receptor antagonist, on gastrointestinal and colonic transit remain unclear. AIM: To compare the effects of placebo, codeine, subcutaneous (s.c.) MNTX and codeine with s.c. MNTX on gastrointestinal and co...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2036.2010.04422.x

データ提供：米国国立医学図書館（NLM）

The Curious Case of Methylnaltrexone and Codeine

The world of pain management is a delicate dance between relief and side effects. Researchers are constantly exploring new drugs and combinations to optimize pain control while minimizing unwanted consequences. This study focuses on the interaction between methylnaltrexone (MNTX), a drug used to treat opioid-induced constipation, and codeine, a common pain reliever.

No Interaction Found

The results of this study, like a desert oasis offering no respite from the heat, reveal that MNTX, when administered alone or in combination with codeine, did not significantly alter gastrointestinal or colonic transit. This finding suggests that MNTX does not interfere with the effects of codeine on gut motility.

Implications for Pain Management

These findings provide valuable information for clinicians who treat patients with opioid-induced constipation. Knowing that MNTX does not interfere with codeine's effects on gut transit can help guide treatment decisions and optimize patient care.

Dr. Camel's Conclusion

This study is a reminder that the journey of pain management is paved with careful observation and research. While MNTX might not be a solution for codeine-induced constipation, it serves as an important stepping stone in the quest for safer and more effective pain management strategies.

Date :
  1. Date Completed 2011-03-14
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

20839388

DOI: Digital Object Identifier

10.1111/j.1365-2036.2010.04422.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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