Drug safety is a barrier to the discovery and development of new androgen receptor antagonists.

Author: ArezzoJoseph C, AttarRicardo M, BalogAaron, CarBruce D, DinchukJoseph E, FosterWilliam R, GanJinping, GottardisMarco M, LevesquePaul C, ObermeierMary T, PowlinStephanie S, SalvatiMark E, ShiHong

Paper Details 
Original Abstract of the Article :
Androgen receptor (AR) antagonists are part of the standard of care for prostate cancer. Despite the almost inevitable development of resistance in prostate tumors to AR antagonists, no new AR antagonists have been approved for over a decade. Treatment failure is due in part to mutations that increa...See full text at original site
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引用元:
https://doi.org/10.1002/pros.21263

データ提供:米国国立医学図書館(NLM)

The Challenge of Developing New Androgen Receptor Antagonists

The development of [new drugs] is a complex and often challenging process. This research examines the difficulties encountered in developing [new androgen receptor antagonists], crucial for treating [prostate cancer]. Despite the emergence of [resistance to existing AR antagonists], no new drugs in this class have been approved in over a decade. The study explores the reasons behind this lack of progress, highlighting the [challenges of developing drugs that effectively target mutated androgen receptors]. The study underscores the need for [a deeper understanding of the mechanisms underlying drug resistance] to facilitate the development of [novel and effective AR antagonists].

Understanding the Barriers to Drug Development

This research provides valuable insights into the [complexities of drug development], particularly in the area of [prostate cancer treatment]. The study's findings highlight the [need for innovative strategies] to overcome the [challenges of drug resistance]. This knowledge is essential for guiding future research efforts and ultimately developing [more effective treatment options] for patients with [prostate cancer].

The Quest for New Treatment Options

The fight against [prostate cancer] requires continuous research and development of [new and effective treatment options]. This study emphasizes the importance of [understanding the mechanisms of drug resistance] to overcome these challenges. By [exploring new approaches] and [addressing the limitations of existing treatments], researchers can pave the way for [a brighter future] for those battling [prostate cancer].

Dr. Camel's Conclusion

Imagine a camel trying to navigate a shifting desert landscape, encountering unexpected obstacles and challenges. Developing new androgen receptor antagonists is like navigating that complex terrain. This research sheds light on the obstacles we face, providing valuable insights into the challenges of drug resistance. It's a reminder that the quest for new treatments requires a persistent and innovative spirit, much like a camel navigating the desert.

Date :
  1. Date Completed 2011-04-08
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

20878947

DOI: Digital Object Identifier

10.1002/pros.21263

SNS
PICO Info
in preparation
Languages

English

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