Paper Details

  1. Home
  2. Paper Details

Effects of magnesium-aluminum hydroxide and calcium carbonate antacids on bioavailability of ofloxacin.

Author: FlorS, GuayD R, MatzkeG R, OpsahlJ A, TackK

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Magnesium-aluminum hydroxide antacids may interfere with the bioavailability of ofloxacin, while calcium carbonate antacids do not. It is recommended to separate the administration of these antacids and ofloxacin by at least 2 hours.
Paper Details　
Original Abstract of the Article :
The effects of 15- and 5-ml doses of magnesium-aluminum hydroxide (MAH) and calcium carbonate (CC) antacids, respectively, on the bioavailability of ofloxacin after single oral 400-mg doses of ofloxacin were investigated in a 32-subject, randomized, crossover, open-label study. On four separate occa...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1128/AAC.34.12.2436

データ提供：米国国立医学図書館（NLM）

Antacids and Antibiotics: A Tale of Interactions

This research explores the potential interactions between [antacids] and the antibiotic [ofloxacin]. The study employed a [randomized, crossover, open-label] design to investigate the impact of [magnesium-aluminum hydroxide (MAH)] and [calcium carbonate (CC)] antacids on the bioavailability of ofloxacin. The findings revealed that [CC antacids] did not significantly affect the absorption of ofloxacin, regardless of the timing of administration. However, [MAH antacids] administered [2 hours before] ofloxacin showed a slight but statistically significant reduction in ofloxacin bioavailability. This suggests that while both antacids generally do not interfere with ofloxacin's effectiveness, a [2-hour interval] should be maintained between their administrations.

Important Considerations for Medication Interactions

This study emphasizes the importance of considering potential interactions between different medications. While both antacids are generally safe, it's important to be aware of their potential impact on the effectiveness of other medications. It's always a good idea to consult with your doctor or pharmacist to ensure that your medications are compatible and that you are receiving the best possible treatment.

Avoiding Medication Mishaps

This research highlights the need to be mindful of medication interactions, even with seemingly innocuous over-the-counter medications like antacids. By being aware of potential interactions and discussing them with your healthcare providers, you can avoid potential complications and ensure the effectiveness of your medications. Remember, knowledge is power, and it can help you navigate the complex world of medications with confidence.

Dr.Camel's Conclusion

Navigating the world of medication interactions can be like navigating a vast desert, with many hidden dangers lurking beneath the surface. This research sheds light on the potential pitfalls of combining antacids with certain antibiotics, and reminds us to always be cautious and informed when it comes to our health.

Date :
  1. Date Completed 1991-05-20
  2. Date Revised 2021-05-26
Further Info :

Pubmed ID

2088202

DOI: Digital Object Identifier

10.1128/AAC.34.12.2436

Related Literature

Article Analysis
・Effects of aluminum hydroxide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.