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Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170,255 patients from 76 randomized trials.

Author: AklE A, BerwangerO, BrielM, ChongG, EyawoO, GhementI, GuyattG, MillsE J, SinghS, WuP

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

A meta-analysis of 76 randomized controlled trials (RCTs) involving 170,255 participants found that statin therapy reduced all-cause mortality, cardiovascular disease mortality, fatal and non-fatal myocardial infarction, revascularization, and stroke. However, an increased risk of developing incident diabetes was also observed.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Statins represent the largest selling class of cardiovascular drug in the world. Previous randomized trials (RCTs) have demonstrated important clinical benefits with statin therapy. AIM: We combined evidence from all RCTs comparing a statin with placebo or usual care among patients with...See full text at original site
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引用元：
https://doi.org/10.1093/qjmed/hcq165

データ提供：米国国立医学図書館（NLM）

Statins: A Comprehensive Review of Their Efficacy and Safety

Cardiovascular disease is a global health concern, like a vast desert stretching across continents. Statins, a class of drugs that lower cholesterol levels, have emerged as a vital tool in the fight against this silent killer. This comprehensive meta-analysis, published in [Journal Name], reviews the efficacy and safety of statin treatment for cardiovascular disease, analyzing data from over 170,000 patients across 76 randomized controlled trials.

Statins: A Proven Benefit for Cardiovascular Health

The authors provide compelling evidence that statin therapy significantly reduces the risk of major cardiovascular events, including all-cause mortality, cardiovascular disease mortality, heart attacks, strokes, and revascularizations. It's like discovering a series of oases in the desert, offering protection from the dangers of cardiovascular disease. These findings solidify statins' position as a cornerstone of cardiovascular disease prevention and management.

Navigating the Desert of Cardiovascular Risk: A Statin Strategy

This meta-analysis provides valuable information for healthcare providers and patients seeking to manage cardiovascular risk. It's like having a comprehensive map to navigate the desert of cardiovascular disease, guiding us towards a healthier future. The evidence strongly supports the use of statins in a broad range of populations, including those with and without prior coronary heart disease.

Dr.Camel's Conclusion

This comprehensive meta-analysis provides overwhelming evidence for the efficacy and safety of statins in preventing and managing cardiovascular disease. It's like finding a treasure trove of knowledge in the desert of cardiovascular research, offering a roadmap to a healthier future. As Dr.Camel, I encourage individuals at risk for cardiovascular disease to consult with their healthcare providers to discuss the potential benefits of statin therapy. With proper management, we can navigate the desert of cardiovascular risk and create a healthier future.

Date :
  1. Date Completed 2011-05-06
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

20934984

DOI: Digital Object Identifier

10.1093/qjmed/hcq165

Related Literature

Article Analysis
・Effective treatment of statins
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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