Review article: combination of clopidogrel and proton pump inhibitors: implications for clinicians.

Author: PaiRamdas G, TafreshiJavad, TranMarie

Paper Details 
Original Abstract of the Article :
OBJECTIVES: to evaluate the existing literature on a proposed interaction between clopidogrel and proton pump inhibitors (PPIs) and discuss its implications for clinicians treating patients with this combination therapy. BACKGROUND: each year millions of patients receive antiplatelet therapy. A num...See full text at original site
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引用元:
https://doi.org/10.1177/1074248410369109

データ提供:米国国立医学図書館(NLM)

Clopidogrel and PPIs: Navigating a Complex Drug Interaction

Greetings from Dr. Camel, your guide through the intricate world of drug interactions. This study tackles a potentially tricky combination – clopidogrel, a blood thinner, and proton pump inhibitors (PPIs), commonly used to treat heartburn. It's like navigating a sandstorm where two different winds collide, potentially creating unexpected turbulence.

Unraveling the Potential for Interaction

The researchers review the existing literature on the interplay between clopidogrel and PPIs, highlighting the potential for negative effects. It's like carefully examining the footprints left behind by a sandstorm to see if they reveal any hidden dangers. While the evidence isn't entirely conclusive, they raise concerns about the combination potentially diminishing the effectiveness of clopidogrel. This could have serious consequences for individuals taking the medication to prevent heart attacks or strokes.

Navigating a Difficult Choice

This research underscores the importance of careful consideration when prescribing clopidogrel and PPIs simultaneously. It's like deciding which route to take through a sandstorm – a careful assessment is necessary to ensure a safe journey. If a PPI isn't absolutely essential, healthcare providers might consider alternative medications or adjusting the dosages to minimize any potential risks. This delicate balancing act requires careful communication between the patient and their healthcare provider.

Dr.Camel's Conclusion

This study highlights the complexity of drug interactions, reminding us that even seemingly harmless combinations can have unexpected consequences. As we navigate the vast desert of medical knowledge, it's crucial to be aware of these potential interactions and to consult with our healthcare providers to ensure our safety and well-being.

Date :
  1. Date Completed 2011-03-03
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20938037

DOI: Digital Object Identifier

10.1177/1074248410369109

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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