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Effect of erythromycin on the oro-caecal transit time in man.

Author: GordinA, JauhonenP, KesäniemiA, LehtolaJ, WikbergR

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Erythromycin shortens oro-caecal transit time in humans, with erythromycin stearate having a more pronounced effect than erythromycin acistrate.
Paper Details　
Original Abstract of the Article :
Erythromycins often cause gastrointestinal side-effects due to an increase in motility or to change in the intestinal bacterial flora. In order to evaluate the effect of erythromycin on gastrointestinal motility. 11 healthy volunteers were given placebo, erythromycin stearate (ES) 1000 mg or a thera...See full text at original site
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引用元：
https://doi.org/10.1007/BF00316094

データ提供：米国国立医学図書館（NLM）

Erythromycin: A Speedy Journey Through the Digestive Desert

Erythromycin, a common antibiotic, is often associated with gastrointestinal side effects. This study takes us on a journey through the digestive desert, investigating the effect of erythromycin on oro-caecal transit time in healthy volunteers. The researchers conducted a double-blind trial to compare the effects of erythromycin stearate (ES), erythromycin acistrate (EA), and placebo on oro-caecal transit time, which is the time it takes for food to travel from the mouth to the cecum.

A Faster Trip: Erythromycin and Oro-Caecal Transit Time

The study found that both erythromycin stearate and erythromycin acistrate significantly shortened the oro-caecal transit time compared to placebo. Erythromycin stearate had a greater effect on transit time than erythromycin acistrate, but also caused more gastrointestinal side effects.

Navigating the Digestive Desert: The Impact of Erythromycin

The study highlights the importance of considering the potential impact of erythromycin on gastrointestinal motility, especially in patients with pre-existing digestive conditions. The findings suggest that erythromycin could accelerate the movement of food through the digestive system, potentially leading to diarrhea or other gastrointestinal disturbances.

Dr. Camel's Conclusion

This study provides valuable insights into the effects of erythromycin on oro-caecal transit time. The researchers found that erythromycin can significantly shorten the time it takes for food to travel through the digestive system. This knowledge is important for understanding the potential side effects of erythromycin and for making informed decisions about its use, especially in patients with pre-existing digestive conditions.
Date :
  1. Date Completed 1991-07-10
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

2095341

DOI: Digital Object Identifier

10.1007/BF00316094

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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