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Opioid-induced bowel dysfunction.

Author: ChangHoward Y, LemboAnthony J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Opioids can cause constipation, which is commonly treated with bulking agents, stimulant laxatives, lubiprostone, and tegaserod. However, new drugs, such as methylnaltrexone and alvimopan, have been developed to block opioid receptors in the gut without affecting their pain-relieving effects in the brain.
Paper Details　
Original Abstract of the Article :
Opioid analgesics are commonly prescribed for moderate to severe pain. Opioids exert effects via receptors in the central and enteric nervous systems. Thus, central opioid analgesia can be limited by side effects involving the gastrointestinal tract, particularly by gastrointestinal motility delay. ...See full text at original site
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引用元：
https://doi.org/10.1007/s11938-008-0002-1

データ提供：米国国立医学図書館（NLM）

Opioids and Bowel Dysfunction: A Balancing Act

Opioids, often prescribed for pain management, can sometimes create a tricky situation for the digestive system, much like a desert traveler facing the challenges of a long journey. This review explores the complex relationship between opioids and bowel dysfunction, examining the mechanisms behind this adverse effect and exploring potential solutions.

Managing Opioid-Induced Bowel Dysfunction

The review highlights the impact of opioids on the gastrointestinal tract, particularly their ability to slow down bowel motility. While traditional treatments for opioid-induced bowel dysfunction have shown limited efficacy, recent research has focused on developing more targeted therapies. These new approaches, like a refreshing oasis in the desert of digestive distress, aim to alleviate bowel dysfunction without compromising the pain-relieving effects of opioids. The review also explores the potential of peripheral κ opioid agonists as an alternative strategy for managing bowel dysfunction.

Balancing Pain Relief and Bowel Health

This review, much like a caravan carefully navigating a treacherous desert, emphasizes the importance of finding a balance between pain relief and bowel health. By understanding the mechanisms behind opioid-induced bowel dysfunction and exploring new therapeutic options, clinicians can better manage this common side effect and improve the overall well-being of their patients. This research, like a beacon of hope in the desert of digestive challenges, points toward a brighter future for patients managing pain with opioids.

Dr.Camel's Conclusion

This review delves into the intricate relationship between opioids and bowel dysfunction, highlighting the need for a delicate balancing act in managing pain while preserving digestive health. By exploring innovative therapeutic strategies and gaining a deeper understanding of the mechanisms at play, this research offers a promising path toward more effective and well-tolerated pain management solutions.
Date :
  1. Date Completed 2011-10-06
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

21063859

DOI: Digital Object Identifier

10.1007/s11938-008-0002-1

SNS
PICO Info
in preparation
Languages

English

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