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Possible protein binding displacement interaction between glibenclamide and metolazone.

Author: ColeA, GeorgeS, McBurneyA

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
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Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Metolazone did not significantly affect the protein binding of glibenclamide. This suggests that metolazone is unlikely to cause a clinically significant increase in the free fraction of glibenclamide in patients receiving both drugs.
Paper Details　
Original Abstract of the Article :
The effects of metolazone on the protein binding of glibenclamide were studied. It was found that increasing metolazone concentrations up to 100 ng/ml had no significant effect on the protein binding of glibenclamide studied at 10 micrograms/ml. Metolazone is unlikely to cause a clinically significa...See full text at original site
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引用元：
https://doi.org/10.1007/BF00314813

データ提供：米国国立医学図書館（NLM）

Possible Protein Binding Displacement Interaction Between Glibenclamide and Metolazone

Glibenclamide, a medication used to treat type 2 diabetes, and metolazone, a diuretic used to treat high blood pressure, are like two camels sharing an oasis. They both need to bind to proteins in the body to function, and this study investigated whether they compete for the same protein binding sites.

The study found that metolazone did not significantly affect the protein binding of glibenclamide. This suggests that the two medications are unlikely to interfere with each other's actions when used together.

Medication Interactions: A Balancing Act

This study highlights the importance of considering potential medication interactions. Just as camels need to find their own oases in the desert, medications need to find their own binding sites in the body. Understanding how medications interact can help ensure safe and effective treatment.

Managing Medications: A Team Effort

When taking multiple medications, it's crucial to talk to your healthcare provider. They can help you understand potential interactions and ensure that your medications are working effectively and safely.

Dr. Camel's Conclusion

Just like camels need to find their own paths through the desert, medications need to find their own binding sites in the body. This study suggests that glibenclamide and metolazone can coexist peacefully, but it's always wise to consult with your healthcare provider about any potential medication interactions.

Date :
  1. Date Completed 1990-05-29
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

2109700

DOI: Digital Object Identifier

10.1007/BF00314813

Related Literature

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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