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Effects of prochloraz or propylthiouracil on the cross-talk between the HPG, HPA, and HPT axes in zebrafish.
Author: Al-KhedhairyAbdulaziz, DengJun, GiesyJohn P, HeckerMarkus, LiuChunsheng, ZhangXiaowei, ZhouBingsheng
Original Abstract of the Article :
The objective of this study was to assess chemical-induced effects on cross-talk among the hypothalamic-pituitary-gonad (HPG), hypothalamic-pituitary-adrenal (HPA), and hypothalamic-pituitary-thyroid (HPT) axes of fish. Adult female zebrafish were exposed to 300 μg/L prochloraz (PCZ) or 100 mg/L pro...See full text at original site
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引用元:
https://doi.org/10.1021/es102659p
データ提供:米国国立医学図書館(NLM)
Chemical-Induced Effects on the HPG, HPA, and HPT Axes in Zebrafish
[Zebrafish], a valuable model organism in [biological research], are increasingly used to study the effects of [environmental stressors] on [endocrine systems]. This study examines the impact of two chemicals, [prochloraz (PCZ)] and [propylthiouracil (PTU)], on the [hypothalamic-pituitary-gonad (HPG)], [hypothalamic-pituitary-adrenal (HPA)], and [hypothalamic-pituitary-thyroid (HPT)] axes in adult female zebrafish. The authors utilize [transcriptional profiling] to assess the effects of PCZ and PTU exposure on these key endocrine axes. Their findings demonstrate that both chemicals can disrupt the normal functioning of these axes, highlighting the potential for endocrine disruption from environmental contaminants. This research underscores the importance of understanding the effects of environmental stressors on endocrine systems, particularly in the context of human health and wildlife conservation.
Endocrine Disruption: A Hidden Threat to Zebrafish Health
This study provides valuable insights into the potential for endocrine disruption from environmental contaminants, focusing on the effects of prochloraz (PCZ) and propylthiouracil (PTU) on the HPG, HPA, and HPT axes in zebrafish. The authors' findings demonstrate that both chemicals can significantly disrupt the normal functioning of these crucial endocrine systems, highlighting the potential for widespread health consequences in both fish populations and potentially other species, including humans. This research underscores the importance of continued monitoring of environmental contaminants and their potential impact on endocrine systems.
Protecting the Environment: Understanding Endocrine Disruption
This study underscores the importance of understanding the potential impact of environmental contaminants on endocrine systems, particularly in the context of human health and wildlife conservation. The authors' findings demonstrate that prochloraz (PCZ) and propylthiouracil (PTU) can significantly disrupt the HPG, HPA, and HPT axes in zebrafish, highlighting the need for continued research and monitoring to address potential endocrine disruption from environmental stressors. By understanding the mechanisms of endocrine disruption, we can develop strategies to protect both human and environmental health.
Dr. Camel's Conclusion
Just as a camel's ability to thrive in harsh desert environments relies on a delicate balance within its body, understanding the impact of environmental contaminants on endocrine systems is crucial for protecting both human and wildlife health. This study reveals the potential for endocrine disruption from chemicals like prochloraz (PCZ) and propylthiouracil (PTU) in zebrafish, highlighting the need for continued research and monitoring to safeguard the health of both humans and the environment.
Date :
- Date Completed 2011-03-29
- Date Revised 2013-11-21
Further Info :
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