The associative factors of delayed-onset rhabdomyolysis in patients with doxylamine overdose.

Author: JeongSeung Hee, JeongWon Jung, KimHan Joon, KimJi Hoon, KimSoo Hyun, OhSang Hoon, ParkKyu Nam, WeeJung Hee, YounChun Song

Paper Details 
Original Abstract of the Article :
OBJECTIVES: The aim of this study was to investigate the associative factors of rhabdomyolysis in patients with doxylamine overdose who had normal creatine phosphokinase levels at admission. METHODS: This study included 169 patients who visited the emergency department of a tertiary teaching hospit...See full text at original site
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引用元:
https://doi.org/10.1016/j.ajem.2010.10.032

データ提供:米国国立医学図書館(NLM)

Delayed-Onset Rhabdomyolysis in Doxylamine Overdose: Identifying Risk Factors

Doxylamine, an over-the-counter antihistamine, is commonly used for treating allergies. However, overdose can lead to serious complications, including rhabdomyolysis, a breakdown of muscle tissue that can cause kidney damage. This study investigated the factors associated with delayed-onset rhabdomyolysis in patients presenting to the emergency department after doxylamine overdose. The researchers analyzed data from 169 patients who had ingested doxylamine, focusing on demographic information, clinical variables, and laboratory data. Their analysis revealed that delayed-onset rhabdomyolysis was significantly associated with the amount of doxylamine ingested and heart rate at admission.

Recognizing the Risk of Delayed-Onset Rhabdomyolysis

This study highlights the importance of recognizing the risk of delayed-onset rhabdomyolysis in patients who have ingested doxylamine. The study's findings suggest that patients with a higher doxylamine ingestion or elevated heart rate at admission are at increased risk for this complication. This underscores the need for close monitoring and prompt intervention in such cases.

Promoting Safety: Educating Patients and Healthcare Providers

This research emphasizes the importance of patient education and healthcare provider awareness regarding the potential for delayed-onset rhabdomyolysis in doxylamine overdose. By understanding the risk factors and recognizing the signs and symptoms of this complication, healthcare providers can effectively monitor patients and intervene promptly to prevent serious consequences.

Dr.Camel's Conclusion

Just as a desert traveler needs to be wary of mirages, healthcare professionals need to be mindful of the potential for delayed-onset rhabdomyolysis in doxylamine overdose. This study underscores the importance of recognizing risk factors and implementing preventive measures to ensure the safety of patients who have ingested doxylamine. By working together, we can create a safer environment for patients and navigate the challenges of managing drug overdose effectively.

Date :
  1. Date Completed 2011-11-29
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

21159475

DOI: Digital Object Identifier

10.1016/j.ajem.2010.10.032

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