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Mu-opioid and noradrenergic α(2)-adrenoceptor contributions to the effects of tapentadol on spinal electrophysiological measures of nociception in nerve-injured rats.

Author: BannisterKirsty, BeeLucy A, DickensonAnthony H, RahmanWahida

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tapentadol, a drug that stimulates mu-opioid receptors (MOR) and acts as a noradrenaline reuptake inhibitor (NRI), is effective in reducing neuropathic pain. This study investigated its mechanism of action in an animal model of neuropathic pain.
Paper Details　
Original Abstract of the Article :
Multiple pathological mechanisms at multiple sensory sites may underlie the pain that follows nerve injury. This provides a basis for recommending more than one agent, either sequentially or in combination, for its treatment. According to this premise, new drugs that combine different mechanisms of ...See full text at original site
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引用元：
https://doi.org/10.1016/j.pain.2010.10.004

データ提供：米国国立医学図書館（NLM）

Tapentadol for Neuropathic Pain: A Multifaceted Approach

This research explores the effectiveness of tapentadol, a drug that acts on both mu-opioid receptors and as a noradrenaline reuptake inhibitor, in treating neuropathic pain. It's like finding a desert oasis that offers not only water, but also shade and protection from the sun. This research aims to understand how tapentadol works and its potential to alleviate neuropathic pain.

Tapentadol: Targeting Multiple Pain Pathways

The study reveals that tapentadol effectively reduces pain in nerve-injured rats, likely by acting on both mu-opioid receptors and noradrenergic α(2)-adrenoceptors in the spinal cord. It's like finding a desert oasis that offers multiple sources of relief, providing a comprehensive solution to the challenges of the harsh desert environment.

Understanding the Mechanisms of Pain Relief

This study deepens our understanding of how tapentadol works and its potential to provide relief from neuropathic pain. It's like uncovering the secrets of a hidden oasis, revealing its intricate network of water sources and its ability to sustain life in the desert.

Dr.Camel's Conclusion

This study provides valuable insights into the potential of tapentadol as a treatment for neuropathic pain. By understanding how tapentadol works on both mu-opioid receptors and as a noradrenaline reuptake inhibitor, researchers can develop more effective treatments for this debilitating condition.

Date :
  1. Date Completed 2011-04-14
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

21187272

DOI: Digital Object Identifier

10.1016/j.pain.2010.10.004

Related Literature

Article Analysis
・Effects of tapentadol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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