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Statins for secondary prevention of cardiovascular disease: the right dose.

Author: SnapinnSteven M, SpectorReynold

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

While statins are proven to be life-saving for coronary artery disease patients, the optimal dose remains debated. Analyses of three large studies suggest that increasing simvastatin or atorvastatin dose to 80 mg does not improve mortality and may increase adverse reactions, suggesting a single dose of 40 mg is sufficient for most patients.
Paper Details　
Original Abstract of the Article :
Since the publication of the 4S trial in 1994, there has emerged a consensus that statins save lives and decrease myocardial infarctions and strokes in coronary artery disease (CAD) patients irrespective of baseline serum cholesterol. However, there is controversy over the correct dose and the utili...See full text at original site
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引用元：
https://doi.org/10.1159/000322999

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Cholesterol: The Right Dose for Heart Health

Cardiovascular disease, a vast and treacherous desert in the landscape of human health, requires careful navigation. This research delves into the optimal dose of statins, a common medication used to lower cholesterol, exploring the delicate balance between effectiveness and safety in the fight against this prevalent condition. The researchers carefully analyzed the data from several large-scale clinical trials to determine the most effective and cost-effective approach to statin therapy.

A Beacon in the Desert: Optimal Statin Dose for Heart Health

The research revealed that a single, safe dose of statins, such as 40mg of simvastatin or atorvastatin, is likely the most effective and cost-effective approach for most patients with coronary artery disease. While higher doses might lead to a slight decrease in some adverse events, they offer no significant benefit in terms of mortality or other major outcomes. This finding provides valuable guidance for healthcare professionals, helping them navigate the desert of cholesterol management with greater precision.

A Balanced Approach to Cholesterol Management

This research offers a beacon of hope in the desert of cardiovascular disease, highlighting the importance of a balanced approach to statin therapy. By focusing on a single, safe dose, we can maximize the benefits of this medication while minimizing the potential for adverse effects. This approach is not only cost-effective but also promotes medication adherence, a key factor in managing chronic conditions.

Dr.Camel's Conclusion

This research demonstrates the importance of careful navigation in the desert of cardiovascular disease, emphasizing the need to find the right dose of statins to achieve optimal health outcomes. By embracing a balanced approach, we can provide patients with the best possible care, ensuring they receive the right treatment at the right dose, and ultimately improving their chances of living long and healthy lives.

Date :
  1. Date Completed 2011-06-20
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

21228612

DOI: Digital Object Identifier

10.1159/000322999

Related Literature

Article Analysis
・Effective treatment of statins
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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