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Insulin-like growth factor-1 in psoriatic plaques treated with PUVA and methotrexate.

Author: AminI, El-KomyM, KadryD, ShakerO, ZeidO A, ZidanA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Psoriasis is thought to be caused by the activation of immune cells and the release of chemicals that promote inflammation and skin growth. Treatments for psoriasis, such as PUVA and methotrexate, have been shown to improve symptoms and reduce excessive skin growth.
Paper Details　
Original Abstract of the Article :
The pathogenesis of psoriasis is thought to depend on the activation of immune cells and their secreted cytokines, chemokines and growth factors like IGF-1 which may contribute to the epidermal hyperplasia of psoriasis. Treatment of psoriasis with PUVA and methotrexate are associated with clinical i...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1468-3083.2010.03966.x

データ提供：米国国立医学図書館（NLM）

Psoriasis: A Skin Condition with Intricate Mechanisms

The skin is a fascinating landscape, and psoriasis, a chronic skin condition, presents its own unique challenges. This study explores the intricate mechanisms behind psoriasis, specifically focusing on the role of insulin-like growth factor-1 (IGF-1) in the development of psoriatic plaques.

IGF-1: A Potential Player in Psoriasis

The study suggests that IGF-1, like a desert wind, plays a role in the epidermal hyperplasia characteristic of psoriasis. The researchers investigated the effects of PUVA and methotrexate, two common treatments for psoriasis, on IGF-1 levels. The results indicate that these treatments may exert their therapeutic effects by influencing IGF-1 activity.

Navigating the Terrain of Psoriasis

This study sheds light on the complex pathways involved in psoriasis. It underscores the importance of understanding the role of growth factors, such as IGF-1, in the development and treatment of this condition. As we continue to explore the desert of psoriasis research, a deeper understanding of these mechanisms may lead to more targeted and effective treatments.

Dr. Camel's Conclusion

Psoriasis, like a shifting sand dune, is a complex condition with intricate mechanisms. This study provides valuable insights into the role of IGF-1 in its development. By understanding these pathways, we can develop more targeted and effective treatments for psoriasis, ultimately leading to a brighter future for those living with this condition.

Date :
  1. Date Completed 2012-01-23
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

21241374

DOI: Digital Object Identifier

10.1111/j.1468-3083.2010.03966.x

Related Literature

Article Analysis
・Effective treatment of psoriasis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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