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[Efficacy and safety of lanthanum carbonate in chronic kidney disease patients with hyperphosphataemia].

Author: LavilleMaurice

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Lanthanum carbonate, a calcium-free phosphate binder, is effective and safe for managing hyperphosphatemia in patients with chronic kidney disease. The drug has minimal digestive absorption and is rapidly excreted by the hepatobiliary system. Long-term follow-up revealed no bone or liver toxicity. The most common side effects were gastrointestinal and occurred at a similar incidence as placebo and other phosphate binders.
Paper Details　
Original Abstract of the Article :
Hyperphosphataemia is a frequent complication in patients with chronic kidney disease and is associated with increased cardiovascular morbidity. Lanthanum carbonate is a calcium-free phosphate binder indicated in patients with chronic kidney disease. Its digestive absorption is minimal (<0,002%). Th...See full text at original site
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引用元：
https://doi.org/10.1016/j.nephro.2010.12.005

データ提供：米国国立医学図書館（NLM）

Lanthanum Carbonate: A Promising Treatment for Hyperphosphataemia in Chronic Kidney Disease

Chronic kidney disease (CKD) can be a challenging desert to navigate, with a variety of complications that require careful management. Hyperphosphataemia, a condition characterized by elevated phosphate levels in the blood, is a common complication of CKD. This study examines the efficacy and safety of lanthanum carbonate, a calcium-free phosphate binder, as a potential treatment for hyperphosphataemia in patients with CKD.

Understanding the Mechanism of Action

Lanthanum carbonate works by binding to phosphate in the gut, preventing its absorption into the bloodstream. This mechanism helps to control hyperphosphataemia, reducing the risk of associated cardiovascular complications. The study highlights the minimal digestive absorption of lanthanum carbonate, minimizing potential systemic side effects. Long-term follow-up revealed no evidence of bone or liver toxicity, reassuring patients about its safety profile.

Balancing Benefits and Risks

The study emphasizes the importance of careful monitoring and management of hyperphosphataemia in patients with CKD. Lanthanum carbonate has demonstrated efficacy and a favorable safety profile, offering a promising treatment option for this challenging condition. However, it's important to be aware of potential gastrointestinal side effects, which are commonly reported, and to discuss any concerns with a healthcare professional.

Dr.Camel's Conclusion

Managing CKD is like navigating a vast desert, with hyperphosphataemia being a potential oasis of trouble. This study presents lanthanum carbonate as a promising camel for tackling this challenge, effectively binding phosphate and minimizing its absorption. While the oasis might offer some side effects, the long-term safety and efficacy make it a valuable tool in managing this condition. Remember, it's essential to consult your healthcare professional to determine the best path forward!

Date :
  1. Date Completed 2011-11-15
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

21247818

DOI: Digital Object Identifier

10.1016/j.nephro.2010.12.005

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in preparation
Languages

French

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