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Effect of Bushen Huoxue Decoction on the orphan receptor and tyrosine hydroxylase in the brain of rats with Parkinson's disease.

Author: LiuYi, WangHai-Ming, YangMing-Hui

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Bushen Huoxue Decoction (BHD) was effective in treating Parkinson's disease (PD) in rats. In a study of 58 rats with PD, BHD was associated with significant improvements in behavioral symptoms, increased Nurr1 mRNA expression, and increased TH positive cells in the substantia nigra.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To explore the effect of Bushen Huoxue Decoction (BHD) on the orphan receptor (Nurr1) and tyrosine hydroxylase (TH) in the brain of rats with Parkinson's disease (PD). METHODS: One hundred and twenty SD rats were divided into 100 in the model group and 20 in the normal control group, fif...See full text at original site
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引用元：
https://doi.org/10.1007/s11655-011-0618-1

データ提供：米国国立医学図書館（NLM）

Bushen Huoxue Decoction: A Potential Oasis for Parkinson's Disease

The world of neuroscience is often a labyrinthine journey, exploring the intricate pathways of the brain. Parkinson's disease, a neurodegenerative disorder characterized by movement impairments, poses a particularly challenging landscape. This study delves into the potential of Bushen Huoxue Decoction (BHD), a traditional Chinese medicine, in addressing the symptoms of Parkinson's disease.

BHD: A Promising Path in the Desert of Parkinson's

The study investigated BHD's effects on orphan receptor (Nurr1) and tyrosine hydroxylase (TH), key players in the brain's dopamine pathways. The findings revealed that BHD significantly enhanced Nurr1 mRNA expression and increased TH positive cells in the substantia nigra, the brain region affected by Parkinson's.

Repairing the Damaged Path: BHD's Potential

These findings suggest that BHD could potentially treat Parkinson's by promoting neuronal repair and enhancing dopamine production. This is like discovering a hidden spring that replenishes the parched landscape of the brain, offering hope for restoration and recovery.

Dr. Camel's Conclusion

This study offers a promising lead in the search for effective treatments for Parkinson's disease. It suggests that traditional Chinese medicine, like BHD, may hold valuable therapeutic potential. However, further research is needed to fully understand its efficacy and safety. It's a journey of discovery, akin to a camel traversing a vast desert, where every new finding reveals a hidden oasis of hope.

Date :
  1. Date Completed 2011-05-02
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21258896

DOI: Digital Object Identifier

10.1007/s11655-011-0618-1

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